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• W1969937619 abstract "Introduction involved knitted Dacron that required preclotting. The antibiotic mixture was added to the blood used for Despite routine antibiotic prophylaxis, graft infection preclotting in the hope that it would remain in the graft interstices. Subsequently it was realised that a occurs after 3–5% of all prosthetic vascular reconstructions. The complication is a major burden to ligand would be necessary to bind the antibiotic to the graft. Various attempts were made, principally vascular surgeons and their patients, with significant time and cost implications. Management can be difin North America, using several different surfactants including benzalkonium chloride and silver-allantoin ficult and the outcome is often disappointing. Recent research interest has focused on attempts to develop to provide non-covalent bonding directly to the graft surface. More recently, coated grafts have been dean infection-resistant prosthetic graft, principally by impregnating antibiotic onto its surface. veloped to prevent leakage of blood through the graft fabric. It has been possible to attach antibiotic to the collagen coat of a Dacron graft using ligands such as triodecylmethylammonium chloride. Despite exInfection-resistant Graft: Theoretical Aspects perimental work detailing their potential benefit, these attempts to create an off-the-shelf antibiotic graft have It is believed that most graft infection is the result of proved cumbersome and expensive. implantation of pathogenic bacteria at, or soon after, Many surgeons presently employ coated Dacron the time of surgery. Contamination may be hidden grafts that have been developed to prevent interstitial underneath a healed wound, or perhaps more often, bleeding. Recently it has been shown that antibiotic the result of progression of a local wound infection to can attach to the surface coating of these Dacron grafts involve the graft fabric (one reason why the aetiology by simple passive diffusion. Although less effective in of wound and graft infections are similar). A theoretical collagen, rifampicin has been shown to bind to the way to reduce the rate of graft infection is to imgelatin coating of a Dacron graft to produce the first pregnate the graft fabric with an antibiotic (or antiimpregnated graft suitable for large scale clinical triseptic) to prevent bacterial adherence. The concept of als. antibiotic impregnation of vascular grafts has been espoused for almost two decades and this report reviews the progress with this technology. One reason for the slow progress is that licensing authorities have The Rifampicin-bonded Graft regarded novel off-the-shelf antibiotic bonded grafts as a new device and required formal trials for reThe combination of an existing graft with a licensed antibiotic has the most immediate promise for progistration. Initial attempts to create an infection-resistant graft gress. The addition of rifampicin to a gelatin-coated" @default.
• W1969937619 created "2016-06-24" @default.
• W1969937619 creator A5072554058 @default.
• W1969937619 date "2000-11-01" @default.
• W1969937619 modified "2023-09-25" @default.
• W1969937619 title "The Current Role of Rifampicin-impregnated Grafts: Pragmatism Versus Science" @default.
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• W1969937619 doi "https://doi.org/10.1053/ejvs.2000.1197" @default.
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