Matches in SemOpenAlex for { <https://semopenalex.org/work/W1969940343> ?p ?o ?g. }
- W1969940343 endingPage "11" @default.
- W1969940343 startingPage "1" @default.
- W1969940343 abstract "Tuberculosis remains one of the major infectious diseases, which continues to pose a major global health problem. Transgenic plants may serve as bioreactors to produce heterologous proteins including antibodies, antigens, and hormones. In the present study, a genetic construct has been designed that comprises the Mycobacterium tuberculosis genes cfp10, esat6 and dIFN gene, which encode deltaferon, a recombinant analog of the human γ -interferon designed for expression in plant tissues. This construct was transferred to the carrot ( Daucus carota L.) genome by Agrobacterium -mediated transformation. This study demonstrates that the fusion protein CFP10-ESAT6-dIFN is synthesized in the transgenic carrot storage roots. The protein is able to induce both humoral and cell-mediated immune responses in laboratory animals (mice) when administered either orally or by injection. It should be emphasized that M. tuberculosis antigens contained in the fusion protein have no cytotoxic effect on peripheral blood mononuclear cells." @default.
- W1969940343 created "2016-06-24" @default.
- W1969940343 creator A5006613097 @default.
- W1969940343 creator A5022189001 @default.
- W1969940343 creator A5022500607 @default.
- W1969940343 creator A5025536080 @default.
- W1969940343 creator A5029776039 @default.
- W1969940343 creator A5047287634 @default.
- W1969940343 creator A5071496379 @default.
- W1969940343 creator A5079857236 @default.
- W1969940343 creator A5081341999 @default.
- W1969940343 creator A5087939577 @default.
- W1969940343 date "2015-01-01" @default.
- W1969940343 modified "2023-10-18" @default.
- W1969940343 title "Transgenic Carrot Expressing Fusion Protein Comprising<i>M. tuberculosis</i>Antigens Induces Immune Response in Mice" @default.
- W1969940343 cites W1964431647 @default.
- W1969940343 cites W1981605167 @default.
- W1969940343 cites W1983763479 @default.
- W1969940343 cites W1985368312 @default.
- W1969940343 cites W1989461230 @default.
- W1969940343 cites W1997354058 @default.
- W1969940343 cites W1997758800 @default.
- W1969940343 cites W1998806628 @default.
- W1969940343 cites W1999676950 @default.
- W1969940343 cites W2000584312 @default.
- W1969940343 cites W2001343915 @default.
- W1969940343 cites W2002615289 @default.
- W1969940343 cites W2006751824 @default.
- W1969940343 cites W2012975359 @default.
- W1969940343 cites W2017303675 @default.
- W1969940343 cites W2018848205 @default.
- W1969940343 cites W2019431372 @default.
- W1969940343 cites W2022564504 @default.
- W1969940343 cites W2024788967 @default.
- W1969940343 cites W2030366638 @default.
- W1969940343 cites W2031725338 @default.
- W1969940343 cites W2038855911 @default.
- W1969940343 cites W2052413997 @default.
- W1969940343 cites W2053885770 @default.
- W1969940343 cites W2057776973 @default.
- W1969940343 cites W2065014293 @default.
- W1969940343 cites W2083218471 @default.
- W1969940343 cites W2102317010 @default.
- W1969940343 cites W2106428834 @default.
- W1969940343 cites W2106525393 @default.
- W1969940343 cites W2124716034 @default.
- W1969940343 cites W2125888491 @default.
- W1969940343 cites W2128635872 @default.
- W1969940343 cites W2131539898 @default.
- W1969940343 cites W2132368987 @default.
- W1969940343 cites W2135506301 @default.
- W1969940343 cites W2156139946 @default.
- W1969940343 cites W2156436209 @default.
- W1969940343 cites W2161794466 @default.
- W1969940343 cites W2162124052 @default.
- W1969940343 cites W2171924190 @default.
- W1969940343 cites W2401647551 @default.
- W1969940343 cites W2418647141 @default.
- W1969940343 cites W4293247451 @default.
- W1969940343 doi "https://doi.org/10.1155/2015/417565" @default.
- W1969940343 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4407408" @default.
- W1969940343 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/25949997" @default.
- W1969940343 hasPublicationYear "2015" @default.
- W1969940343 type Work @default.
- W1969940343 sameAs 1969940343 @default.
- W1969940343 citedByCount "18" @default.
- W1969940343 countsByYear W19699403432015 @default.
- W1969940343 countsByYear W19699403432016 @default.
- W1969940343 countsByYear W19699403432017 @default.
- W1969940343 countsByYear W19699403432018 @default.
- W1969940343 countsByYear W19699403432019 @default.
- W1969940343 countsByYear W19699403432020 @default.
- W1969940343 countsByYear W19699403432021 @default.
- W1969940343 countsByYear W19699403432022 @default.
- W1969940343 countsByYear W19699403432023 @default.
- W1969940343 crossrefType "journal-article" @default.
- W1969940343 hasAuthorship W1969940343A5006613097 @default.
- W1969940343 hasAuthorship W1969940343A5022189001 @default.
- W1969940343 hasAuthorship W1969940343A5022500607 @default.
- W1969940343 hasAuthorship W1969940343A5025536080 @default.
- W1969940343 hasAuthorship W1969940343A5029776039 @default.
- W1969940343 hasAuthorship W1969940343A5047287634 @default.
- W1969940343 hasAuthorship W1969940343A5071496379 @default.
- W1969940343 hasAuthorship W1969940343A5079857236 @default.
- W1969940343 hasAuthorship W1969940343A5081341999 @default.
- W1969940343 hasAuthorship W1969940343A5087939577 @default.
- W1969940343 hasBestOaLocation W19699403431 @default.
- W1969940343 hasConcept C102230213 @default.
- W1969940343 hasConcept C104317684 @default.
- W1969940343 hasConcept C123894998 @default.
- W1969940343 hasConcept C142724271 @default.
- W1969940343 hasConcept C147483822 @default.
- W1969940343 hasConcept C154317977 @default.
- W1969940343 hasConcept C159047783 @default.
- W1969940343 hasConcept C202751555 @default.
- W1969940343 hasConcept C203014093 @default.
- W1969940343 hasConcept C204241405 @default.
- W1969940343 hasConcept C2777975735 @default.