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- W1969940756 abstract "Introduction: The inability of axons to regenerate after injury is perplexing. Although limited axonal outgrowth has been demonstrated with peripheral nerve grafts, Schwann cell implants, and various nerve growth factors, successful regeneration of severed CST axons with functional restoration is yet to be achieved. In earlier studies, we found that inosine, a purine nuceleoside, was a potent promoter of axogenesis in vitro. Consequently, we wanted to test its in vivo role in conjunction with cellular implants in promoting CST axon regeneration after SCI. Methods: Adult, male S.D. rats (N = 42) underwent unilateral transection of their CSTs, 1mm rostral to the pyramidal decussation. Cellular implants consisting of either neural stem cells or olfactory ensheathing cells (OECs) were transplanted into the lesions immediately following injury. Osmotic minipumps implanted into either the axotomized or nonaxotomized sensorimotor cortex, continuously delivered inosine (experimental, N = 22) or PBS (control, N = 20) for 14..." @default.
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- W1969940756 date "2000-08-01" @default.
- W1969940756 modified "2023-09-26" @default.
- W1969940756 title "731 Extensive Axon Regeneration in the Adult Rat Corticospinal Tract after Spinal Cord Injury" @default.
- W1969940756 doi "https://doi.org/10.1097/00006123-200008000-00079" @default.
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