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- W1969941208 endingPage "F948" @default.
- W1969941208 startingPage "F941" @default.
- W1969941208 abstract "Treatment of aging men and women with testosterone supplements is increasing. The supplements are given to postmenopausal women mainly to improve their libido and to aging men to improve muscle mass and bone strength, to improve libido and quality of life, to prevent and treat osteoporosis, and, with the phosphodiesterase-5 inhibitors, such as sildenafil, to treat erectile dysfunction. The increased use of testosterone supplements in aging individuals has occurred despite the fact that there have been no rigorous clinical trials examining the effects of chronic testosterone on the cardiovascular-renal disease risk. Studies in humans and animals have suggested that androgens can increase blood pressure and compromise renal function. Androgens have been shown to increase tubular sodium and water reabsorption and activate various vasoconstrictor systems in the kidney, such as the renin-angiotensin system and endothelin. There is also evidence that androgens may increase oxidative stress. Furthermore, the kidney contains the enzymes necessary to produce androgens de novo. This review presents an overview of the data from human and animal studies in which the role of androgens in promoting renal and cardiovascular diseases has been investigated." @default.
- W1969941208 created "2016-06-24" @default.
- W1969941208 creator A5025753116 @default.
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- W1969941208 creator A5036893031 @default.
- W1969941208 creator A5077062656 @default.
- W1969941208 creator A5085377296 @default.
- W1969941208 date "2005-11-01" @default.
- W1969941208 modified "2023-09-27" @default.
- W1969941208 title "Testosterone supplementation in aging men and women: possible impact on cardiovascular-renal disease" @default.
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- W1969941208 doi "https://doi.org/10.1152/ajprenal.00034.2005" @default.
- W1969941208 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/16210452" @default.
- W1969941208 hasPublicationYear "2005" @default.
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