FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1969945802> ?p ?o ?g. }

• W1969945802 endingPage "376" @default.
• W1969945802 startingPage "368" @default.
• W1969945802 abstract "Raloxifene is a selective estrogen receptor modulator (SERM) that prevents bone loss. Although it is largely used for the treatment of osteoporosis, the mechanisms by which this compound modulates the activity of bone cells are still poorly understood. In this study we investigate whether raloxifene affects osteoclast and osteoblast activity in vitro. Bone marrow cultures were established from neonatal mice and treated with 1,25(OH)2 vitamin D3 (VitD3, 10−8 mol/L) to induce osteoclast generation. Similar to 17β-estradiol, raloxifene significantly reduced the number of osteoclasts in a concentration-dependent manner, with maximal inhibition at 10−11 mol/L (−48%). However, as for 17β-estradiol, at a high concentration (10−7 mol/L), the inhibitory effect of raloxifene was abolished. In a pit assay, raloxifene inhibited bone resorption. A maximal effect was observed at 10−9 mol/L, and maintained at a high concentration, indicating that inhibition of osteoclast formation and inhibition of bone resorption may be due to activation of, at least in part, different pathways. Osteoblasts from neonatal mice calvariae were also exposed to raloxifene. In these cells, this compound induced a concentration-dependent increase of proliferation, which was blocked by the estrogen-receptor antagonist ICI 164,384. Raloxifene also increased the osteoblast-specific transcription factor Cbfa1/Runx2 and α2 procollagen type I chain mRNAs, with a pattern that only partially coincided with that of 17β-estradiol. Consistent with decreased osteoclastogenesis, raloxifene inhibited the mRNA expression of interleukin (IL)-1β and IL-6 at a low concentration, but not at a high concentration, whereas 17β-estradiol had similar effects on IL-6 and inhibited IL-1β at both concentrations. Furthermore, both compounds were able to inhibit tumor necrosis factor (TNF)-α-induced IL-1β, but not IL-6, increase. In conclusion, these data show that raloxifene negatively modulates osteoclasts, and positively affects osteoblasts, suggesting not only an antiresorptive role, but also an osteoblast stimulatory role." @default.
• W1969945802 created "2016-06-24" @default.
• W1969945802 creator A5001875881 @default.
• W1969945802 creator A5004842183 @default.
• W1969945802 creator A5006150148 @default.
• W1969945802 creator A5008913414 @default.
• W1969945802 creator A5025714200 @default.
• W1969945802 creator A5061191212 @default.
• W1969945802 creator A5063960004 @default.
• W1969945802 creator A5068614870 @default.
• W1969945802 creator A5085077525 @default.
• W1969945802 date "2002-02-01" @default.
• W1969945802 modified "2023-10-13" @default.
• W1969945802 title "The selective estrogen receptor modulator raloxifene regulates osteoclast and osteoblast activity in vitro" @default.
• W1969945802 cites W1479966533 @default.
• W1969945802 cites W1561293749 @default.
• W1969945802 cites W1570147293 @default.
• W1969945802 cites W1775749144 @default.
• W1969945802 cites W1967640708 @default.
• W1969945802 cites W1972708863 @default.
• W1969945802 cites W1976535459 @default.
• W1969945802 cites W1981845849 @default.
• W1969945802 cites W1997812904 @default.
• W1969945802 cites W1997883187 @default.
• W1969945802 cites W2005011653 @default.
• W1969945802 cites W2006311160 @default.
• W1969945802 cites W2007688596 @default.
• W1969945802 cites W2011031168 @default.
• W1969945802 cites W2012938408 @default.
• W1969945802 cites W2016674232 @default.
• W1969945802 cites W2019152720 @default.
• W1969945802 cites W2019308648 @default.
• W1969945802 cites W2020521731 @default.
• W1969945802 cites W2027215054 @default.
• W1969945802 cites W2029105382 @default.
• W1969945802 cites W2031741414 @default.
• W1969945802 cites W2047475075 @default.
• W1969945802 cites W2048352187 @default.
• W1969945802 cites W2062729355 @default.
• W1969945802 cites W2063039411 @default.
• W1969945802 cites W2066062971 @default.
• W1969945802 cites W2070217710 @default.
• W1969945802 cites W2075786281 @default.
• W1969945802 cites W2082385204 @default.
• W1969945802 cites W2084535197 @default.
• W1969945802 cites W2101729306 @default.
• W1969945802 cites W2111510880 @default.
• W1969945802 cites W2112629831 @default.
• W1969945802 cites W2121829164 @default.
• W1969945802 cites W2140086733 @default.
• W1969945802 cites W2159207368 @default.
• W1969945802 cites W2163126741 @default.
• W1969945802 cites W2171604853 @default.
• W1969945802 cites W2172157728 @default.
• W1969945802 cites W4229739170 @default.
• W1969945802 cites W4231419829 @default.
• W1969945802 cites W4236319195 @default.
• W1969945802 cites W4237275596 @default.
• W1969945802 cites W4241168804 @default.
• W1969945802 cites W4248398150 @default.
• W1969945802 cites W4252543199 @default.
• W1969945802 cites W4294216491 @default.
• W1969945802 doi "https://doi.org/10.1016/s8756-3282(01)00685-8" @default.
• W1969945802 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/11856644" @default.
• W1969945802 hasPublicationYear "2002" @default.
• W1969945802 type Work @default.
• W1969945802 sameAs 1969945802 @default.
• W1969945802 citedByCount "141" @default.
• W1969945802 countsByYear W19699458022012 @default.
• W1969945802 countsByYear W19699458022013 @default.
• W1969945802 countsByYear W19699458022014 @default.
• W1969945802 countsByYear W19699458022015 @default.
• W1969945802 countsByYear W19699458022016 @default.
• W1969945802 countsByYear W19699458022017 @default.
• W1969945802 countsByYear W19699458022018 @default.
• W1969945802 countsByYear W19699458022019 @default.
• W1969945802 countsByYear W19699458022020 @default.
• W1969945802 countsByYear W19699458022021 @default.
• W1969945802 countsByYear W19699458022022 @default.
• W1969945802 countsByYear W19699458022023 @default.
• W1969945802 crossrefType "journal-article" @default.
• W1969945802 hasAuthorship W1969945802A5001875881 @default.
• W1969945802 hasAuthorship W1969945802A5004842183 @default.
• W1969945802 hasAuthorship W1969945802A5006150148 @default.
• W1969945802 hasAuthorship W1969945802A5008913414 @default.
• W1969945802 hasAuthorship W1969945802A5025714200 @default.
• W1969945802 hasAuthorship W1969945802A5061191212 @default.
• W1969945802 hasAuthorship W1969945802A5063960004 @default.
• W1969945802 hasAuthorship W1969945802A5068614870 @default.
• W1969945802 hasAuthorship W1969945802A5085077525 @default.
• W1969945802 hasConcept C121608353 @default.
• W1969945802 hasConcept C126322002 @default.
• W1969945802 hasConcept C134018914 @default.
• W1969945802 hasConcept C170493617 @default.
• W1969945802 hasConcept C185592680 @default.
• W1969945802 hasConcept C202751555 @default.
• W1969945802 hasConcept C2776033226 @default.
• W1969945802 hasConcept C2776363554 @default.

• next