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- W1969946355 abstract "The preparation of 22,23-3H-vitamin D4 (specific activity = 100,000 dpm/0.025 μg has been described, its biopotency in rats established, and its metabolism in rats studied as compared with 1, 2-3H-vitamin D3. The highest concentrations of 3H from a 0.25-μg intravenous dose of 3H-vitamin D4 were found in bone cells and intestinal mucosa. Liver initially (within 1 hour) accumulated much of the radioactivity but released it again quite rapidly. Other tissues attained a maximum of radioactivity at about 4 hours after dosage and declined slowly thereafter. The radioactivity from 22,23-3H-vitamin D4 in the tissues declined more rapidly than that from 1,2-3H-vitamin D3 but increased more rapidly in the intestinal contents and feces, which suggests that vitamin D4 or a metabolite thereof is excreted more rapidly than vitamin D3 and thereby renders it ineffective earlier." @default.
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- W1969946355 date "1968-01-01" @default.
- W1969946355 modified "2023-09-29" @default.
- W1969946355 title "Synthesis, biological activity, and metabolism of 22, 23−3H-vitamin D4" @default.
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- W1969946355 doi "https://doi.org/10.1016/0003-9861(68)90310-x" @default.
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