Matches in SemOpenAlex for { <https://semopenalex.org/work/W1969951716> ?p ?o ?g. }
- W1969951716 endingPage "1990" @default.
- W1969951716 startingPage "1981" @default.
- W1969951716 abstract "While the phenomenon of slow axonal transport is widely agreed upon, its underlying mechanism has been controversial for decades. There is now persuasive evidence that several different mechanisms could contribute to slow axonal transport. Yet proponents of different theories have been hesitant to explicitly integrate what were, at least initially, opposing models. We suggest that slow transport is a multivariate phenomenon that arises through mechanisms that minimally include: molecular motor-based transport of polymers and soluble proteins as multi-protein complexes; diffusion; and en bloc transport of the axonal framework by low velocity transport and towed growth (due to increases in body size). In addition to integrating previously described mechanisms of transport, we further suggest that only a subset of transport modes operate in a given neuron depending on the region, length, species, cell type, and developmental stage. We believe that this multivariate approach to slow axonal transport better explains its complex phenomenology: including its bi-directionality; the differing velocities of transport depending on cargo, as well differing velocities due to anatomy, cell type and developmental stage." @default.
- W1969951716 created "2016-06-24" @default.
- W1969951716 creator A5079059260 @default.
- W1969951716 creator A5086301605 @default.
- W1969951716 date "2008-06-01" @default.
- W1969951716 modified "2023-10-17" @default.
- W1969951716 title "What is slow axonal transport?" @default.
- W1969951716 cites W1487136062 @default.
- W1969951716 cites W1518239715 @default.
- W1969951716 cites W1554750796 @default.
- W1969951716 cites W1577821810 @default.
- W1969951716 cites W1585886861 @default.
- W1969951716 cites W1591219763 @default.
- W1969951716 cites W172569123 @default.
- W1969951716 cites W1828088162 @default.
- W1969951716 cites W1853541631 @default.
- W1969951716 cites W1957057114 @default.
- W1969951716 cites W1963744588 @default.
- W1969951716 cites W1964238319 @default.
- W1969951716 cites W1964476192 @default.
- W1969951716 cites W1965112294 @default.
- W1969951716 cites W1965901737 @default.
- W1969951716 cites W1967437498 @default.
- W1969951716 cites W1968141091 @default.
- W1969951716 cites W197416499 @default.
- W1969951716 cites W1976053673 @default.
- W1969951716 cites W1979814640 @default.
- W1969951716 cites W1980953373 @default.
- W1969951716 cites W1981973341 @default.
- W1969951716 cites W1985864093 @default.
- W1969951716 cites W1987847886 @default.
- W1969951716 cites W1988736583 @default.
- W1969951716 cites W1990842234 @default.
- W1969951716 cites W1992888811 @default.
- W1969951716 cites W2001122288 @default.
- W1969951716 cites W2006268333 @default.
- W1969951716 cites W2011672695 @default.
- W1969951716 cites W2012922169 @default.
- W1969951716 cites W2013631479 @default.
- W1969951716 cites W2014370318 @default.
- W1969951716 cites W2015229379 @default.
- W1969951716 cites W2016186706 @default.
- W1969951716 cites W2018551806 @default.
- W1969951716 cites W2018976375 @default.
- W1969951716 cites W2025884663 @default.
- W1969951716 cites W2025889905 @default.
- W1969951716 cites W2029268455 @default.
- W1969951716 cites W2029838113 @default.
- W1969951716 cites W2041102637 @default.
- W1969951716 cites W2042186926 @default.
- W1969951716 cites W2042532717 @default.
- W1969951716 cites W2043811492 @default.
- W1969951716 cites W2048538066 @default.
- W1969951716 cites W2048973430 @default.
- W1969951716 cites W2049653874 @default.
- W1969951716 cites W2049779694 @default.
- W1969951716 cites W2050077296 @default.
- W1969951716 cites W2052319008 @default.
- W1969951716 cites W2055329935 @default.
- W1969951716 cites W2060863809 @default.
- W1969951716 cites W2063270168 @default.
- W1969951716 cites W2064181097 @default.
- W1969951716 cites W2065042412 @default.
- W1969951716 cites W2065797752 @default.
- W1969951716 cites W2065849781 @default.
- W1969951716 cites W2066275176 @default.
- W1969951716 cites W2068277146 @default.
- W1969951716 cites W2069456899 @default.
- W1969951716 cites W2073999002 @default.
- W1969951716 cites W2076535162 @default.
- W1969951716 cites W2076909889 @default.
- W1969951716 cites W2078588365 @default.
- W1969951716 cites W2079269040 @default.
- W1969951716 cites W2086927886 @default.
- W1969951716 cites W2089514910 @default.
- W1969951716 cites W2092552346 @default.
- W1969951716 cites W2094388738 @default.
- W1969951716 cites W2101786243 @default.
- W1969951716 cites W2103868443 @default.
- W1969951716 cites W2107143290 @default.
- W1969951716 cites W2123818144 @default.
- W1969951716 cites W2124046153 @default.
- W1969951716 cites W2127124583 @default.
- W1969951716 cites W2132583909 @default.
- W1969951716 cites W2134134192 @default.
- W1969951716 cites W2137137258 @default.
- W1969951716 cites W2143352071 @default.
- W1969951716 cites W2146014141 @default.
- W1969951716 cites W2146640900 @default.
- W1969951716 cites W2147943204 @default.
- W1969951716 cites W2149762749 @default.
- W1969951716 cites W2151512547 @default.
- W1969951716 cites W2151560607 @default.
- W1969951716 cites W2152397595 @default.
- W1969951716 cites W2152602648 @default.
- W1969951716 cites W2154846674 @default.
- W1969951716 cites W2156114501 @default.
- W1969951716 cites W2158537052 @default.