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• W1969952005 abstract "In 1993 the World Health Organization (WHO) declared tuberculosis a global public health emergency, the only disease so far to warrant that designation. The declaration galvanized an awareness in the medical community of the magnitude of the global tuberculosis problem. This paper will review the epidemiological data from WHO, the Centers for Disease Control and Prevention (CDC) and other groups and describe recent research developments.Based on well-recorded history, WHO has calculated that there has been no significant decrease in the world-wide mortality due to tuberculosis since before the time of Koch in 1882, and that the advent of sanatoria and chemotherapy, which drastically reduced tuberculosis in the more developed countries, had no profound effect on the global problem [1,2]. The tuberculosis problem in India alone has not changed since its independence in the late 1940s. Then and now, about 13 million people, i.e., 1.5% of the total population, suffer from active pulmonary tuberculosis and, of these, about 6 million are sputum-positive and therefore highly infectious [3].Some of the well-known truisms about tuberculosis are that the disease is emerging, reemerging, recalcitrant and resistant to treatment in many global areas; responsible for more human deaths than any other single infectious agent — 26% of all preventable deaths, 7% of all deaths [4]; and inherently resistant to many common antibiotics, such as the β-lactams, due to inherent β-lactamases and its peculiar mycolic acid-containing cell wall barrier [5].Epidemiologists have estimated, based on tuberculin skin test reactivity, that about one-third of the world's population, i.e., about 1.7 billion people, are infected with M. tuberculosis [4]. They also calculated that each year, 8–10 million new cases of tuberculosis occur, i.e., an estimated 90 million cases over this decade, and almost 3 million people die from tuberculosis …" @default.
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• W1969952005 date "1997-08-01" @default.
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• W1969952005 title "Tuberculosis in the context of emerging and reemerging diseases" @default.
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• W1969952005 doi "https://doi.org/10.1111/j.1574-695x.1997.tb01054.x" @default.
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