FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1969966564> ?p ?o ?g. }

• W1969966564 endingPage "165" @default.
• W1969966564 startingPage "158" @default.
• W1969966564 abstract "The present study was undertaken to assess the possible protective effects of sitagliptin, a dipeptidyl peptidase 4-inhibitor (DPP4), against Nω-nitro-L-arginine methyl ester (L-NAME) induced hypertensive nephropathy in rats. Hypertension was induced in adult rats by administration of L-NAME for 6 weeks. Rats were treated with sitagliptin (10 mg/kg/day or 30 mg/kg/day) for six weeks. Chronic L-NAME administration resulted in depletion of serum nitric oxide (NO) associated with elevation in the mean arterial pressure. When compared with the control group; serum urea, serum creatinine, albuminuria, urinary N-acetyl-ß-d-glucosaminidase (NAG) level and renal tissue malondialdhyde (MDA) content were significantly elevated, while creatinine clearance, serum level of glucagon like peptide-1 (GLP-1) as well as renal tissue superoxide dismutase (SOD) and glutathione peroxidase (GSH-Px) activities were signifcantly decreased in L-NAME treated group. Renal expression of mRNA for eNOS and GLP-1 receptors were reduced in the L-NAME treated group as compared with the control group. Treatment with sitagliptin (10 mg/kg or 30 mg/kg) successfully ameliorated the deleterious effects of L-NAME on the all tested parameters. Our study indicates a novel protective effect of sitagliptin against L-NAME induced hypertensive nephropathy. An effect which is mediated through, increasing serum level of GLP-1, upregulation of GLP-1 receptors, which in turn, lead to induction of expression eNOS, increased serum NO level, tandem with decreased lipid perodixation and restore the antioxidant defense mechanisms. It is worth mentioning that the effects produced by sitaglipin (30 mg/kg) were superior to the effects obtained by the lower dose." @default.
• W1969966564 created "2016-06-24" @default.
• W1969966564 creator A5014233332 @default.
• W1969966564 creator A5049527513 @default.
• W1969966564 date "2013-11-01" @default.
• W1969966564 modified "2023-10-10" @default.
• W1969966564 title "Renoprotective effect of sitagliptin against hypertensive nephropathy induced by chronic administration of L-NAME in rats: Role of GLP-1 and GLP-1 receptor" @default.
• W1969966564 cites W1012070930 @default.
• W1969966564 cites W1964986459 @default.
• W1969966564 cites W1975781920 @default.
• W1969966564 cites W1984664578 @default.
• W1969966564 cites W1989421333 @default.
• W1969966564 cites W1990089345 @default.
• W1969966564 cites W1990802251 @default.
• W1969966564 cites W1997358375 @default.
• W1969966564 cites W2002149579 @default.
• W1969966564 cites W2014083905 @default.
• W1969966564 cites W2017351479 @default.
• W1969966564 cites W2025071203 @default.
• W1969966564 cites W2027132230 @default.
• W1969966564 cites W2036975667 @default.
• W1969966564 cites W2039260613 @default.
• W1969966564 cites W2044696025 @default.
• W1969966564 cites W2052301782 @default.
• W1969966564 cites W2053144819 @default.
• W1969966564 cites W2061314911 @default.
• W1969966564 cites W2065399019 @default.
• W1969966564 cites W2067935925 @default.
• W1969966564 cites W2069915524 @default.
• W1969966564 cites W2078822231 @default.
• W1969966564 cites W2081568683 @default.
• W1969966564 cites W2088933145 @default.
• W1969966564 cites W2090360729 @default.
• W1969966564 cites W2091193879 @default.
• W1969966564 cites W2093821653 @default.
• W1969966564 cites W2097571046 @default.
• W1969966564 cites W2106036385 @default.
• W1969966564 cites W2107277218 @default.
• W1969966564 cites W2107998222 @default.
• W1969966564 cites W2110827050 @default.
• W1969966564 cites W2113985146 @default.
• W1969966564 cites W2123629330 @default.
• W1969966564 cites W2124284996 @default.
• W1969966564 cites W2128215212 @default.
• W1969966564 cites W2128601172 @default.
• W1969966564 cites W2135957458 @default.
• W1969966564 cites W2140980725 @default.
• W1969966564 cites W2166051277 @default.
• W1969966564 cites W2168397692 @default.
• W1969966564 cites W2336492617 @default.
• W1969966564 cites W4253015600 @default.
• W1969966564 cites W4376595514 @default.
• W1969966564 cites W7690208 @default.
• W1969966564 doi "https://doi.org/10.1016/j.ejphar.2013.10.033" @default.
• W1969966564 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/24238127" @default.
• W1969966564 hasPublicationYear "2013" @default.
• W1969966564 type Work @default.
• W1969966564 sameAs 1969966564 @default.
• W1969966564 citedByCount "34" @default.
• W1969966564 countsByYear W19699665642014 @default.
• W1969966564 countsByYear W19699665642015 @default.
• W1969966564 countsByYear W19699665642016 @default.
• W1969966564 countsByYear W19699665642017 @default.
• W1969966564 countsByYear W19699665642018 @default.
• W1969966564 countsByYear W19699665642019 @default.
• W1969966564 countsByYear W19699665642020 @default.
• W1969966564 countsByYear W19699665642021 @default.
• W1969966564 countsByYear W19699665642023 @default.
• W1969966564 crossrefType "journal-article" @default.
• W1969966564 hasAuthorship W1969966564A5014233332 @default.
• W1969966564 hasAuthorship W1969966564A5049527513 @default.
• W1969966564 hasConcept C126322002 @default.
• W1969966564 hasConcept C134018914 @default.
• W1969966564 hasConcept C2777180221 @default.
• W1969966564 hasConcept C2779284873 @default.
• W1969966564 hasConcept C2779922275 @default.
• W1969966564 hasConcept C2780306776 @default.
• W1969966564 hasConcept C555293320 @default.
• W1969966564 hasConcept C71924100 @default.
• W1969966564 hasConceptScore W1969966564C126322002 @default.
• W1969966564 hasConceptScore W1969966564C134018914 @default.
• W1969966564 hasConceptScore W1969966564C2777180221 @default.
• W1969966564 hasConceptScore W1969966564C2779284873 @default.
• W1969966564 hasConceptScore W1969966564C2779922275 @default.
• W1969966564 hasConceptScore W1969966564C2780306776 @default.
• W1969966564 hasConceptScore W1969966564C555293320 @default.
• W1969966564 hasConceptScore W1969966564C71924100 @default.
• W1969966564 hasIssue "1-3" @default.
• W1969966564 hasLocation W19699665641 @default.
• W1969966564 hasLocation W19699665642 @default.
• W1969966564 hasOpenAccess W1969966564 @default.
• W1969966564 hasPrimaryLocation W19699665641 @default.
• W1969966564 hasRelatedWork W2063464815 @default.
• W1969966564 hasRelatedWork W2104058374 @default.
• W1969966564 hasRelatedWork W2164375919 @default.
• W1969966564 hasRelatedWork W2278512696 @default.
• W1969966564 hasRelatedWork W2577123180 @default.
• W1969966564 hasRelatedWork W2740693425 @default.

• next