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- W1969968379 abstract "Since minoxidil was previously shown to raise plasma renin activity (PRA) but not the plasma aldosterone concentration (PAC), the effect of minoxidil on the rate of aldosterone metabolic clearance was studies. After the addition of minoxidil to the antihypertensive regimen of 7 hypertensive patients, the aldosterone metabolic clearance rate increased from 1,110 $ 91 to 1,570 $ 180 liters/day (p < 0.01), an overall increase of 41%. Hepatic blood flow, estimates from the clearance from plasma of indocyanine green, was increased in a group of minoxidil-treated patients compared to a comparable group not treated with minoxidil (p < 0.01). Thus, although minoxidil induces an increase in PRA, PAC dose not change, since aldosterone metabolic clearance increases. Minoxidil increases hepatic blood flow, and it was probably by this mechanism that the drug accelerated the rate of aldosterone clearance." @default.
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- W1969968379 date "1980-01-01" @default.
- W1969968379 modified "2023-10-14" @default.
- W1969968379 title "Increased Aldosterone Metabolic Clearance in Hypertensive Patients Treated with Minoxidil" @default.
- W1969968379 doi "https://doi.org/10.1097/00005344-198000022-00018" @default.
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