FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1969968994> ?p ?o ?g. }

• W1969968994 endingPage "596" @default.
• W1969968994 startingPage "590" @default.
• W1969968994 abstract "<i>Background:</i> Bilirubin, an antioxidant, has been associated with reduced cardiovascular disease risk. A major cause of elevated plasma bilirubin is the common UGT1A1*28 promoter polymorphism in the gene of the bilirubin-conjugating enzyme UDP-glucuronosyltransferase 1A1, which reduces transcription by 70%. Earlier studies reporting a protective effect of bilirubin on stroke have not included analysis of UGT1A1*28. The purpose of this study is to investigate if bilirubin and UGT1A1*28 are protective against ischemic stroke in a prospective case-referent setting. <i>Methods:</i> Cases with first-ever ischemic stroke (n = 231; median lag time 4.9 years) and 462 matched referents from the Northern Sweden Health and Disease Study Cohort were included. Plasma bilirubin was measured and UGT1A1*28 was analyzed by fragment analysis. <i>Results:</i> Plasma bilirubin was lower in cases than in referents, but the difference reached significance only for women. The UGT1A1*28 polymorphism (allele frequency 30%) showed a strong gene-dose relationship with bilirubin levels both among cases and referents, but was not associated with risk for stroke. Among multiple other variables analyzed, the strongest correlation with bilirubin was found for plasma iron. <i>Conclusions:</i> There was no evidence for a protective effect of the UGT1A1*28 polymorphism against stroke and consequently neither for bilirubin. The findings suggest that other factors influencing the risk for stroke might also affect bilirubin levels." @default.
• W1969968994 created "2016-06-24" @default.
• W1969968994 creator A5028905334 @default.
• W1969968994 creator A5031486216 @default.
• W1969968994 creator A5037092993 @default.
• W1969968994 creator A5058226386 @default.
• W1969968994 creator A5068051213 @default.
• W1969968994 creator A5070039164 @default.
• W1969968994 creator A5086508895 @default.
• W1969968994 creator A5089724775 @default.
• W1969968994 date "2010-01-01" @default.
• W1969968994 modified "2023-10-04" @default.
• W1969968994 title "Bilirubin and UGT1A1*28 Are Not Associated with Lower Risk for Ischemic Stroke in a Prospective Nested Case-Referent Setting" @default.
• W1969968994 cites W1861720226 @default.
• W1969968994 cites W1901338077 @default.
• W1969968994 cites W1977261901 @default.
• W1969968994 cites W1979560937 @default.
• W1969968994 cites W1983329266 @default.
• W1969968994 cites W1987083790 @default.
• W1969968994 cites W1992978747 @default.
• W1969968994 cites W1993719373 @default.
• W1969968994 cites W1995587147 @default.
• W1969968994 cites W2011877873 @default.
• W1969968994 cites W2018847571 @default.
• W1969968994 cites W2024870017 @default.
• W1969968994 cites W2029449918 @default.
• W1969968994 cites W2032786707 @default.
• W1969968994 cites W2049298570 @default.
• W1969968994 cites W2050858963 @default.
• W1969968994 cites W2053161351 @default.
• W1969968994 cites W2053913358 @default.
• W1969968994 cites W2055552531 @default.
• W1969968994 cites W2057765179 @default.
• W1969968994 cites W2064384628 @default.
• W1969968994 cites W2077358733 @default.
• W1969968994 cites W2077998362 @default.
• W1969968994 cites W2081113191 @default.
• W1969968994 cites W2081764647 @default.
• W1969968994 cites W2100996541 @default.
• W1969968994 cites W2105631299 @default.
• W1969968994 cites W2121175586 @default.
• W1969968994 cites W2125826054 @default.
• W1969968994 cites W2125886893 @default.
• W1969968994 cites W2135103569 @default.
• W1969968994 cites W2138737838 @default.
• W1969968994 cites W2144981953 @default.
• W1969968994 cites W2159062914 @default.
• W1969968994 cites W2162584279 @default.
• W1969968994 cites W2165076929 @default.
• W1969968994 doi "https://doi.org/10.1159/000319778" @default.
• W1969968994 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/20948202" @default.
• W1969968994 hasPublicationYear "2010" @default.
• W1969968994 type Work @default.
• W1969968994 sameAs 1969968994 @default.
• W1969968994 citedByCount "19" @default.
• W1969968994 countsByYear W19699689942012 @default.
• W1969968994 countsByYear W19699689942013 @default.
• W1969968994 countsByYear W19699689942014 @default.
• W1969968994 countsByYear W19699689942017 @default.
• W1969968994 countsByYear W19699689942018 @default.
• W1969968994 countsByYear W19699689942019 @default.
• W1969968994 countsByYear W19699689942020 @default.
• W1969968994 countsByYear W19699689942021 @default.
• W1969968994 countsByYear W19699689942022 @default.
• W1969968994 countsByYear W19699689942023 @default.
• W1969968994 crossrefType "journal-article" @default.
• W1969968994 hasAuthorship W1969968994A5028905334 @default.
• W1969968994 hasAuthorship W1969968994A5031486216 @default.
• W1969968994 hasAuthorship W1969968994A5037092993 @default.
• W1969968994 hasAuthorship W1969968994A5058226386 @default.
• W1969968994 hasAuthorship W1969968994A5068051213 @default.
• W1969968994 hasAuthorship W1969968994A5070039164 @default.
• W1969968994 hasAuthorship W1969968994A5086508895 @default.
• W1969968994 hasAuthorship W1969968994A5089724775 @default.
• W1969968994 hasConcept C126322002 @default.
• W1969968994 hasConcept C127413603 @default.
• W1969968994 hasConcept C188816634 @default.
• W1969968994 hasConcept C2777513400 @default.
• W1969968994 hasConcept C2780645631 @default.
• W1969968994 hasConcept C71924100 @default.
• W1969968994 hasConcept C78519656 @default.
• W1969968994 hasConcept C90924648 @default.
• W1969968994 hasConceptScore W1969968994C126322002 @default.
• W1969968994 hasConceptScore W1969968994C127413603 @default.
• W1969968994 hasConceptScore W1969968994C188816634 @default.
• W1969968994 hasConceptScore W1969968994C2777513400 @default.
• W1969968994 hasConceptScore W1969968994C2780645631 @default.
• W1969968994 hasConceptScore W1969968994C71924100 @default.
• W1969968994 hasConceptScore W1969968994C78519656 @default.
• W1969968994 hasConceptScore W1969968994C90924648 @default.
• W1969968994 hasIssue "6" @default.
• W1969968994 hasLocation W19699689941 @default.
• W1969968994 hasLocation W19699689942 @default.
• W1969968994 hasOpenAccess W1969968994 @default.
• W1969968994 hasPrimaryLocation W19699689941 @default.
• W1969968994 hasRelatedWork W2055141553 @default.
• W1969968994 hasRelatedWork W2076993109 @default.
• W1969968994 hasRelatedWork W2159723344 @default.

• next