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• W1969969303 abstract "The hydroxylation of gibberellin (GA) at the 2-position is known as the major cause of inactivation of GAs, whose reaction is catalyzed by 2-oxoglutarate dependent dioxygenases, also termed GA 2-oxidases (GA2oxs). To block GA catabolism in plants, a few chemicals can be used. To obtain novel inhibitors specific to GA2oxs, we performed in vitro random screenings by using (3)H-16,17-dihydro-GA(4) and recombinant Arabidopsis GA2ox2. As a result, one candidate, methyl 6-chloro-3H-1,2,3-benzodithiazole-4-carboxylate 2-oxide (CBTC), was selected from the screening, and was subjected to in-planta evaluations. CBTC promoted both the germination and elongation of Arabidopsis seedlings. This strongly suggests that CBTC inhibits GA2oxs in Arabidopsis with high specificity." @default.
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• W1969969303 date "2010-07-01" @default.
• W1969969303 modified "2023-10-16" @default.
• W1969969303 title "Screening and characterization of an inhibitory chemical specific to Arabidopsis gibberellin 2-oxidases" @default.
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• W1969969303 doi "https://doi.org/10.1016/j.bmcl.2010.05.015" @default.
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