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• W1969969680 abstract "In Brief Although nonsteroidal antiinflammatory drugs (NSAIDs) improve postoperative pain relief after cesarean delivery, they carry potential side effects (e.g., bleeding). Perioperative cyclooxygenase (COX)-2 inhibitors show similar analgesic efficacy to nonsteroidal antiinflammatory drugs in many surgical models but have not been studied after cesarean delivery. We designed this randomized double-blind study to determine the analgesic efficacy and opioid-sparing effects of valdecoxib after cesarean delivery. Healthy patients undergoing elective cesarean delivery under spinal anesthesia were randomized to receive oral valdecoxib 20 mg or placebo every 12 h for 72 h postoperatively. As a result of cyclooxygenase-2 inhibitors safety concerns that became apparent during this study, the study was terminated early after evaluating 48 patients. We found no differences in total analgesic consumption between the valdecoxib and placebo groups (121 ± 70 versus 143 ± 77 morphine mg-equivalents, respectively; P = 0.26). Pain at rest and during activity were similar between the groups despite adequate post hoc power to have detected a clinically significant difference. There were also no differences in IV morphine requirements, time to first analgesic request, patient satisfaction, side effects, breast-feeding success, or functional activity. Postoperative pain was generally well controlled. Adding valdecoxib after cesarean delivery under spinal anesthesia with intrathecal morphine is not supported at this time. IMPLICATIONS: Nonsteroidal antiinflammatory drugs improve postoperative pain after cesarean delivery. No previous study has determined the analgesic efficacy of cyclooxygenase (COX)-2 inhibitors after cesarean delivery. Valdecoxib did not significantly reduce pain or opioid consumption in the 72 h after cesarean delivery. The addition of COX-2 inhibitors to improve post-cesarean pain is not supported at this time." @default.
• W1969969680 created "2016-06-24" @default.
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• W1969969680 date "2006-09-01" @default.
• W1969969680 modified "2023-10-09" @default.
• W1969969680 title "Valdecoxib for Postoperative Pain Management After Cesarean Delivery: A Randomized, Double-Blind, Placebo-Controlled Study" @default.
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• W1969969680 doi "https://doi.org/10.1213/01.ane.0000229702.42426.a6" @default.
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