Matches in SemOpenAlex for { <https://semopenalex.org/work/W1969974695> ?p ?o ?g. }
Showing items 1 to 100 of
100
with 100 items per page.
- W1969974695 endingPage "1280" @default.
- W1969974695 startingPage "1274" @default.
- W1969974695 abstract "The mortality associated with cancer depends upon the ability of malignant cells to invade and metastasise into adjacent and distant regions. Such malignant spread is caused by the acquisition of an invasive phenotype which involves variable changes in cell-cell adhesion, proteolysis of adjoining extracellular matrix molecules, and the ability to move in a directed fashion in response to fixed and soluble gradients. Whilst the degree of variability in the pattern of metastasis is large, several cancers show regional predilections for invasion. Tumour cell heterogeneity and extracellular matrix composition have been shown to account for some regional variations. In this study, an invasion assay was used to assess the invasiveness of HT1080 tumour cells migrating through a collagen gel. Our experiments showed that, in the absence of externally imposed chemical gradients, HT1080 invasiveness was related in a biphasic manner to collagen concentration. Using a mathematical model, developed to study this phenomenon, we predicted that tumour cell proliferation may also be related in a biphasic manner to collagen concentration. This model prediction was confirmed using a combination of collagen gel invasion and proliferation assays. Investigation of the mathematical model suggests that interactions between haptotaxis and proliferation of the HT1080 cells may be responsible for the biphasic dependence of the penetration depth and proliferation on collagen gel concentration. In conclusion, we showed how mathematical methods can be combined with experimental work to provide new and valuable insight into important biological issues." @default.
- W1969974695 created "2016-06-24" @default.
- W1969974695 creator A5080112720 @default.
- W1969974695 creator A5087448925 @default.
- W1969974695 date "1999-08-01" @default.
- W1969974695 modified "2023-09-30" @default.
- W1969974695 title "Extracellular matrix concentration exerts selection pressure on invasive cells" @default.
- W1969974695 cites W1983774546 @default.
- W1969974695 cites W1989597729 @default.
- W1969974695 cites W2027091123 @default.
- W1969974695 cites W2027990964 @default.
- W1969974695 cites W2037375326 @default.
- W1969974695 cites W2044019708 @default.
- W1969974695 cites W2052626837 @default.
- W1969974695 cites W2061158185 @default.
- W1969974695 cites W2068412487 @default.
- W1969974695 cites W2076259473 @default.
- W1969974695 cites W2110586785 @default.
- W1969974695 cites W2124138369 @default.
- W1969974695 cites W2138811906 @default.
- W1969974695 cites W1972810454 @default.
- W1969974695 doi "https://doi.org/10.1016/s0959-8049(99)00125-2" @default.
- W1969974695 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/10615241" @default.
- W1969974695 hasPublicationYear "1999" @default.
- W1969974695 type Work @default.
- W1969974695 sameAs 1969974695 @default.
- W1969974695 citedByCount "105" @default.
- W1969974695 countsByYear W19699746952012 @default.
- W1969974695 countsByYear W19699746952013 @default.
- W1969974695 countsByYear W19699746952014 @default.
- W1969974695 countsByYear W19699746952015 @default.
- W1969974695 countsByYear W19699746952016 @default.
- W1969974695 countsByYear W19699746952017 @default.
- W1969974695 countsByYear W19699746952018 @default.
- W1969974695 countsByYear W19699746952019 @default.
- W1969974695 countsByYear W19699746952020 @default.
- W1969974695 countsByYear W19699746952021 @default.
- W1969974695 countsByYear W19699746952022 @default.
- W1969974695 countsByYear W19699746952023 @default.
- W1969974695 crossrefType "journal-article" @default.
- W1969974695 hasAuthorship W1969974695A5080112720 @default.
- W1969974695 hasAuthorship W1969974695A5087448925 @default.
- W1969974695 hasConcept C106487976 @default.
- W1969974695 hasConcept C11957725 @default.
- W1969974695 hasConcept C121608353 @default.
- W1969974695 hasConcept C12554922 @default.
- W1969974695 hasConcept C1491633281 @default.
- W1969974695 hasConcept C185592680 @default.
- W1969974695 hasConcept C189165786 @default.
- W1969974695 hasConcept C2777751087 @default.
- W1969974695 hasConcept C2779013556 @default.
- W1969974695 hasConcept C28406088 @default.
- W1969974695 hasConcept C43617362 @default.
- W1969974695 hasConcept C54355233 @default.
- W1969974695 hasConcept C55493867 @default.
- W1969974695 hasConcept C62112901 @default.
- W1969974695 hasConcept C85789140 @default.
- W1969974695 hasConcept C86803240 @default.
- W1969974695 hasConcept C95444343 @default.
- W1969974695 hasConcept C96232424 @default.
- W1969974695 hasConceptScore W1969974695C106487976 @default.
- W1969974695 hasConceptScore W1969974695C11957725 @default.
- W1969974695 hasConceptScore W1969974695C121608353 @default.
- W1969974695 hasConceptScore W1969974695C12554922 @default.
- W1969974695 hasConceptScore W1969974695C1491633281 @default.
- W1969974695 hasConceptScore W1969974695C185592680 @default.
- W1969974695 hasConceptScore W1969974695C189165786 @default.
- W1969974695 hasConceptScore W1969974695C2777751087 @default.
- W1969974695 hasConceptScore W1969974695C2779013556 @default.
- W1969974695 hasConceptScore W1969974695C28406088 @default.
- W1969974695 hasConceptScore W1969974695C43617362 @default.
- W1969974695 hasConceptScore W1969974695C54355233 @default.
- W1969974695 hasConceptScore W1969974695C55493867 @default.
- W1969974695 hasConceptScore W1969974695C62112901 @default.
- W1969974695 hasConceptScore W1969974695C85789140 @default.
- W1969974695 hasConceptScore W1969974695C86803240 @default.
- W1969974695 hasConceptScore W1969974695C95444343 @default.
- W1969974695 hasConceptScore W1969974695C96232424 @default.
- W1969974695 hasIssue "8" @default.
- W1969974695 hasLocation W19699746951 @default.
- W1969974695 hasLocation W19699746952 @default.
- W1969974695 hasOpenAccess W1969974695 @default.
- W1969974695 hasPrimaryLocation W19699746951 @default.
- W1969974695 hasRelatedWork W1675599972 @default.
- W1969974695 hasRelatedWork W2027029136 @default.
- W1969974695 hasRelatedWork W2050690016 @default.
- W1969974695 hasRelatedWork W2083693850 @default.
- W1969974695 hasRelatedWork W2100202648 @default.
- W1969974695 hasRelatedWork W2395572556 @default.
- W1969974695 hasRelatedWork W2416128704 @default.
- W1969974695 hasRelatedWork W2901911696 @default.
- W1969974695 hasRelatedWork W2969925635 @default.
- W1969974695 hasRelatedWork W3034274977 @default.
- W1969974695 hasVolume "35" @default.
- W1969974695 isParatext "false" @default.
- W1969974695 isRetracted "false" @default.
- W1969974695 magId "1969974695" @default.
- W1969974695 workType "article" @default.