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• W1969974889 endingPage "33" @default.
• W1969974889 startingPage "13" @default.
• W1969974889 abstract "CRH is produced in the parvocellular division of the PVN and released into the hypophysial portal circulation to stimulate ACTH synthesis and secretion, thus playing a critical role in the HPA axis regulation. The activity of CRH neurons is regulated by humoral factors such as glucocorticoid and IL-1 as well as numerous kinds of neural inputs within and from outside of the hypothalamus. Circulating glucocorticoids readily have access to the CRH neurons and thereby exert a potent inhibitory action on CRH gene transcription. The molecular mechanisms involved in the glucocorticoid negative feedback remain to be fully understood. IL-1, produced in the periphery during the inflammatory process, is a potent stimulatory factor for CRH neurons. It is not yet clear how a protein of this large molecular weight has access to brain tissues through the blood brain barrier, nor is it clear through which neural pathway the IL-1-mediated signal is conveyed to the hypothalamus.A number of neurotransmitter/modulator candidates have been implicated in the regulation of CRH neurons. Functional roles and anatomical pathways have been explored by pharmacological methods, ablation of specific neural pathway(s), and the neural tracingethod. Despite the substantial knowledge produced by these studies, physiological and/or pathophysiological roles of the respective neural circuitry are still obscure.Two major intracellular signal transduction systems, the CAMP-dependent PKA pathway and diacylglycerol-dependent PKC pathway, are implicated in transcriptional regulation of the CRH gene. The functionality of the CRE, 5'-flanking the CRH gene, has been well established in cell culture system transfected with CRH promoter-reporter constructs, thus the cAMP-dependent PKA pathway may play an essential role in CRH gene expression. The role of the PKC pathway is still controversial and requires further exploration." @default.
• W1969974889 created "2016-06-24" @default.
• W1969974889 creator A5026500855 @default.
• W1969974889 creator A5049286080 @default.
• W1969974889 creator A5058687274 @default.
• W1969974889 date "1998-01-01" @default.
• W1969974889 modified "2023-09-25" @default.
• W1969974889 title "Cellular and Extracellular Regulatory Mechanisms of Hypothalamic Corticotropin-Releasing Hormone Neurons." @default.
• W1969974889 cites W1493629431 @default.
• W1969974889 cites W1509046486 @default.
• W1969974889 cites W1519700610 @default.
• W1969974889 cites W1524779116 @default.
• W1969974889 cites W1529067373 @default.
• W1969974889 cites W1546774137 @default.
• W1969974889 cites W1581572500 @default.
• W1969974889 cites W161777585 @default.
• W1969974889 cites W1836407144 @default.
• W1969974889 cites W1961661934 @default.
• W1969974889 cites W1963980710 @default.
• W1969974889 cites W1965337556 @default.
• W1969974889 cites W1965529792 @default.
• W1969974889 cites W1966464425 @default.
• W1969974889 cites W1967619163 @default.
• W1969974889 cites W1971357456 @default.
• W1969974889 cites W1971482865 @default.
• W1969974889 cites W1973645820 @default.
• W1969974889 cites W1974088820 @default.
• W1969974889 cites W1975151126 @default.
• W1969974889 cites W1975575774 @default.
• W1969974889 cites W1976360004 @default.
• W1969974889 cites W1976647119 @default.
• W1969974889 cites W1978051898 @default.
• W1969974889 cites W1978175539 @default.
• W1969974889 cites W1978599015 @default.
• W1969974889 cites W1979447393 @default.
• W1969974889 cites W1979620819 @default.
• W1969974889 cites W1980466482 @default.
• W1969974889 cites W1980664442 @default.
• W1969974889 cites W1981453234 @default.
• W1969974889 cites W1983156080 @default.
• W1969974889 cites W1983436839 @default.
• W1969974889 cites W1984265716 @default.
• W1969974889 cites W1984478526 @default.
• W1969974889 cites W1985598652 @default.
• W1969974889 cites W1986221824 @default.
• W1969974889 cites W1986413865 @default.
• W1969974889 cites W1986445622 @default.
• W1969974889 cites W1988694091 @default.
• W1969974889 cites W1990360138 @default.
• W1969974889 cites W1990421313 @default.
• W1969974889 cites W1991128322 @default.
• W1969974889 cites W1992198720 @default.
• W1969974889 cites W1992338483 @default.
• W1969974889 cites W1994139656 @default.
• W1969974889 cites W1995226963 @default.
• W1969974889 cites W1995667098 @default.
• W1969974889 cites W1996638302 @default.
• W1969974889 cites W1997454604 @default.
• W1969974889 cites W1998389180 @default.
• W1969974889 cites W1999558341 @default.
• W1969974889 cites W1999989426 @default.
• W1969974889 cites W2000849838 @default.
• W1969974889 cites W2000956334 @default.
• W1969974889 cites W2001642111 @default.
• W1969974889 cites W2003603935 @default.
• W1969974889 cites W2004192630 @default.
• W1969974889 cites W2007309883 @default.
• W1969974889 cites W2009064702 @default.
• W1969974889 cites W2009415328 @default.
• W1969974889 cites W2009922975 @default.
• W1969974889 cites W2010584142 @default.
• W1969974889 cites W2011031780 @default.
• W1969974889 cites W2011727899 @default.
• W1969974889 cites W2012382054 @default.
• W1969974889 cites W2012803400 @default.
• W1969974889 cites W2012935173 @default.
• W1969974889 cites W2013177481 @default.
• W1969974889 cites W2013391829 @default.
• W1969974889 cites W2015613847 @default.
• W1969974889 cites W2016405311 @default.
• W1969974889 cites W2016821300 @default.
• W1969974889 cites W2018333777 @default.
• W1969974889 cites W2018919319 @default.
• W1969974889 cites W2021098104 @default.
• W1969974889 cites W2022701325 @default.
• W1969974889 cites W2022760228 @default.
• W1969974889 cites W2023023053 @default.
• W1969974889 cites W2023455262 @default.
• W1969974889 cites W2024273400 @default.
• W1969974889 cites W2025155885 @default.
• W1969974889 cites W2025612606 @default.
• W1969974889 cites W2027259277 @default.
• W1969974889 cites W2029027714 @default.
• W1969974889 cites W2029323039 @default.
• W1969974889 cites W2029891256 @default.
• W1969974889 cites W2030024768 @default.
• W1969974889 cites W2030677119 @default.
• W1969974889 cites W2030711241 @default.

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