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- W1969977506 abstract "A practical and cost-effective synthesis of 3,3-difluoropyrrolidine is reported. The synthesis involves the isolation of two intermediates, which are prepared via two efficient through processes: (1) a Claisen rearrangement followed by a Ru(VIII)-catalyzed oxidation to prepare the 2,2-difluorosuccinic acid and (2) an efficient cyclization to form N-benzyl-3,3-difluoropyrrolidinone followed by BH(3).Me(2)S reduction." @default.
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- W1969977506 date "2005-06-24" @default.
- W1969977506 modified "2023-09-27" @default.
- W1969977506 title "Practical Preparation of 3,3-Difluoropyrrolidine" @default.
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- W1969977506 doi "https://doi.org/10.1021/jo050591h" @default.
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