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- W1969980604 abstract "Glutathione S-transferase (GST) plays a major role in the detoxification of the potent hepatocarcinogen aflatoxin B(1) (AFB(1)). This study evaluated the effects of intermittent exposures to AFB(1) on hepatic and testicular GST in rats. Male Fischer 344 rats were fed diets containing AFB(1) (0, 0.01, 0.04, 0.4 and 1.6 ppm) intermittently at 4-week intervals up to 20 weeks. The control animals were fed an AFB(1)-free NIH-31 diet. Rats consuming diets with 0.01 ppm AFB(1) did not show the induction of hepatic or testicular GST activity. Intermittent exposures to AFB(1) at concentrations of 0.04-1.6 ppm significantly increased the GST activities. The increase of the enzyme activity was proportional to the dose and length of AFB(1) exposure." @default.
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- W1969980604 date "2000-05-01" @default.
- W1969980604 modified "2023-10-01" @default.
- W1969980604 title "Effects of intermittent exposures of aflatoxin B1 on hepatic and testicular glutathione S-transferase in rats" @default.
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- W1969980604 doi "https://doi.org/10.1002/(sici)1099-1263(200005/06)20:3<215::aid-jat649>3.0.co;2-2" @default.
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