FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1970003449> ?p ?o ?g. }

• W1970003449 endingPage "17260" @default.
• W1970003449 startingPage "17253" @default.
• W1970003449 abstract "Epigenetics is emerging as an attractive mechanism to explain the persistent genomic embedding of early-life experiences. Tightly linked to chromatin, which packages DNA into chromosomes, epigenetic marks primarily serve to regulate the activity of genes. DNA methylation is the most accessible and characterized component of the many chromatin marks that constitute the epigenome, making it an ideal target for epigenetic studies in human populations. Here, using peripheral blood mononuclear cells collected from a community-based cohort stratified for early-life socioeconomic status, we measured DNA methylation in the promoter regions of more than 14,000 human genes. Using this approach, we broadly assessed and characterized epigenetic variation, identified some of the factors that sculpt the epigenome, and determined its functional relation to gene expression. We found that the leukocyte composition of peripheral blood covaried with patterns of DNA methylation at many sites, as did demographic factors, such as sex, age, and ethnicity. Furthermore, psychosocial factors, such as perceived stress, and cortisol output were associated with DNA methylation, as was early-life socioeconomic status. Interestingly, we determined that DNA methylation was strongly correlated to the ex vivo inflammatory response of peripheral blood mononuclear cells to stimulation with microbial products that engage Toll-like receptors. In contrast, our work found limited effects of DNA methylation marks on the expression of associated genes across individuals, suggesting a more complex relationship than anticipated." @default.
• W1970003449 created "2016-06-24" @default.
• W1970003449 creator A5001139144 @default.
• W1970003449 creator A5005733297 @default.
• W1970003449 creator A5025043851 @default.
• W1970003449 creator A5033660195 @default.
• W1970003449 creator A5064520181 @default.
• W1970003449 creator A5082761941 @default.
• W1970003449 creator A5088684784 @default.
• W1970003449 date "2012-10-08" @default.
• W1970003449 modified "2023-10-15" @default.
• W1970003449 title "Factors underlying variable DNA methylation in a human community cohort" @default.
• W1970003449 cites W1965262464 @default.
• W1970003449 cites W1967064280 @default.
• W1970003449 cites W1967841068 @default.
• W1970003449 cites W1973778874 @default.
• W1970003449 cites W1979504761 @default.
• W1970003449 cites W1997824331 @default.
• W1970003449 cites W1997890656 @default.
• W1970003449 cites W2002497918 @default.
• W1970003449 cites W2010993240 @default.
• W1970003449 cites W2024103316 @default.
• W1970003449 cites W2026343134 @default.
• W1970003449 cites W2029033394 @default.
• W1970003449 cites W2052314258 @default.
• W1970003449 cites W2054942267 @default.
• W1970003449 cites W2055237453 @default.
• W1970003449 cites W2056040742 @default.
• W1970003449 cites W2057020332 @default.
• W1970003449 cites W2059099579 @default.
• W1970003449 cites W2062449054 @default.
• W1970003449 cites W2065020285 @default.
• W1970003449 cites W2068480672 @default.
• W1970003449 cites W2073393965 @default.
• W1970003449 cites W2074174832 @default.
• W1970003449 cites W2074746593 @default.
• W1970003449 cites W2076472141 @default.
• W1970003449 cites W2091503140 @default.
• W1970003449 cites W2099390922 @default.
• W1970003449 cites W2100552707 @default.
• W1970003449 cites W2103673123 @default.
• W1970003449 cites W2104471815 @default.
• W1970003449 cites W2106670153 @default.
• W1970003449 cites W2108176813 @default.
• W1970003449 cites W2111485719 @default.
• W1970003449 cites W2113588666 @default.
• W1970003449 cites W2113728034 @default.
• W1970003449 cites W2116830437 @default.
• W1970003449 cites W2117347068 @default.
• W1970003449 cites W2123174009 @default.
• W1970003449 cites W2125590226 @default.
• W1970003449 cites W2125700595 @default.
• W1970003449 cites W2128782957 @default.
• W1970003449 cites W2129256542 @default.
• W1970003449 cites W2143858605 @default.
• W1970003449 cites W2146107508 @default.
• W1970003449 cites W2148337554 @default.
• W1970003449 cites W2150671474 @default.
• W1970003449 cites W2154704794 @default.
• W1970003449 cites W2156874253 @default.
• W1970003449 cites W2160704282 @default.
• W1970003449 cites W2167287693 @default.
• W1970003449 cites W2170538199 @default.
• W1970003449 doi "https://doi.org/10.1073/pnas.1121249109" @default.
• W1970003449 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3477380" @default.
• W1970003449 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/23045638" @default.
• W1970003449 hasPublicationYear "2012" @default.
• W1970003449 type Work @default.
• W1970003449 sameAs 1970003449 @default.
• W1970003449 citedByCount "392" @default.
• W1970003449 countsByYear W19700034492012 @default.
• W1970003449 countsByYear W19700034492013 @default.
• W1970003449 countsByYear W19700034492014 @default.
• W1970003449 countsByYear W19700034492015 @default.
• W1970003449 countsByYear W19700034492016 @default.
• W1970003449 countsByYear W19700034492017 @default.
• W1970003449 countsByYear W19700034492018 @default.
• W1970003449 countsByYear W19700034492019 @default.
• W1970003449 countsByYear W19700034492020 @default.
• W1970003449 countsByYear W19700034492021 @default.
• W1970003449 countsByYear W19700034492022 @default.
• W1970003449 countsByYear W19700034492023 @default.
• W1970003449 crossrefType "journal-article" @default.
• W1970003449 hasAuthorship W1970003449A5001139144 @default.
• W1970003449 hasAuthorship W1970003449A5005733297 @default.
• W1970003449 hasAuthorship W1970003449A5025043851 @default.
• W1970003449 hasAuthorship W1970003449A5033660195 @default.
• W1970003449 hasAuthorship W1970003449A5064520181 @default.
• W1970003449 hasAuthorship W1970003449A5082761941 @default.
• W1970003449 hasAuthorship W1970003449A5088684784 @default.
• W1970003449 hasBestOaLocation W19700034491 @default.
• W1970003449 hasConcept C104317684 @default.
• W1970003449 hasConcept C117717151 @default.
• W1970003449 hasConcept C121912465 @default.
• W1970003449 hasConcept C150194340 @default.
• W1970003449 hasConcept C190727270 @default.
• W1970003449 hasConcept C33288867 @default.
• W1970003449 hasConcept C41091548 @default.

• next