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- W1970005140 abstract "The Mini Mental State Examination (MMSE) is the most commonly used brief instrument for assessing cognitive function in both clinical settings and in research. In spite of its briefness and practical usefulness, MMSE had various limitations on its bias (false positive, false negative) by demographic variables and insensitivity to frontal executive dysfunction. In this study, we aimed to investigate whether demographic variable-adjustment and supplementation of frontal executive dysfunction, measured by the Frontal Assessment Battery (FAB) can improve the screening accuracy of MMSE for dementia and its major subtypes in a large community-dwelling population. Five hundred forty-one non-demented comparison (NC) and 474 dementia (320 Alzheimer disease [AD] dementia, 139 non-AD dementia [NAD], and 15 mixed AD plus non-AD dementia [MXD]) individuals living in the community were included. A stepwise multiple linear regression analysis was performed to assess the relative contribution of age, education, and sex on MMSE score in NC. Logistic regression was used to determine whether adding the selected demographic variable or FAB to MMSE provided any additional information for predicting dementia (or its subtype) over that given by MMSE alone. Receiver operating characteristic (ROC) curve analysis was used to assess the utility of MMSE alone and combination of MMSE with FAB, the selected demographic variable, or both as a screen for dementia or its subtypes. Area under the curve (AUC) of ROC curve was compared by using the method of Hanley and Mc-Neil. ROC curve analyses were performed by using MedCalc for Windows, version 12.1 (MedCalc Software, Mariakerke, Belgium). Education-adjusted MMSE (MMSE edu) score showed significantly better screening accuracy for overall dementia, AD, and NAD than MMSE raw score. Weighted sum (WS) scores, derived from logistic regression model including both MMSE and FAB scores, had better screening ability for NAD, but not for overall dementia and AD, than MMSE raw score alone. In addition, education-adjusted WS score showed higher screening accuracy for dementia and NAD than both MMSE edu and WS score. These results strongly support the usefulness of education-adjustment and supplementation of frontal-executive scores to improve screening performance of MMSE for dementia and its subtypes." @default.
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- W1970005140 date "2012-07-01" @default.
- W1970005140 modified "2023-09-23" @default.
- W1970005140 title "P2-427: Improvement of dementia screening accuracy of Mini-Mental State Examination (MMSE) by education-adjustment and supplementation of Frontal Assessment Battery (FAB) performance" @default.
- W1970005140 doi "https://doi.org/10.1016/j.jalz.2012.05.2052" @default.
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