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- W1970010098 abstract "CONSIDERABLE enthusiasm has developed regarding the treatment of gram-negative bacillary meningitis with newly developed broad-spectrum, third-generation cephalosporin antibiotics. 1,2 Compared with other agents such as aminoglycosides or previously available cephalosporins, these antibiotics have remarkable activity against the organisms that cause this life-threatening infection. 3 The degree of penetration across the blood-brain barrier is so much greater for third-generation cephalosporins than the previously utilized antibiotics for gram-negative bacillary meningitis that many investigators now suggest that either cefotaxime sodium or moxalactam disodium is the drug of choice for this infection. 1 Since the proved therapy of intraventricular aminoglycoside administration may be associated with serious hazards, 4 the relative safety of cephalosporins is attractive. The relapse rate, however, has not been determined for this therapy with new cephalosporins. We recently gave one of these agents to a patient with gram-negative bacillary meningitis and observed an adequate initial response followed by relapse of infection." @default.
- W1970010098 created "2016-06-24" @default.
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- W1970010098 date "1982-09-10" @default.
- W1970010098 modified "2023-09-25" @default.
- W1970010098 title "Relapse of Gram-negative Bacillary Meningitis After Cefotaxime Therapy" @default.
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- W1970010098 doi "https://doi.org/10.1001/jama.1982.03330100052031" @default.
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