Matches in SemOpenAlex for { <https://semopenalex.org/work/W1970011172> ?p ?o ?g. }
- W1970011172 endingPage "10687" @default.
- W1970011172 startingPage "10683" @default.
- W1970011172 abstract "Most proteins that activate RNA polymerase II-mediated transcription in eukaryotic cells contain sequence-specific DNA-binding domains and activation regions. The latter bind general transcription factors and/or coactivators and are required for high-level transcription. Their function in vivo is unknown. Since several activation domains bind the TATA-binding protein (TBP), TBP-associated factors, or other general factors in vitro, one role of the activation domain may be to facilitate promoter occupancy by supporting cooperative binding of the activator and general transcription factors. Using the GAL4 system of yeast, we have tested this model in vivo. It is demonstrated that the presence of a TATA box (the TBP binding site) facilitates binding of GAL4 protein to low- and moderate-affinity sites and that the activation domain modulates these effects. These results support the cooperative binding model for activation domain function in vivo." @default.
- W1970011172 created "2016-06-24" @default.
- W1970011172 creator A5000290640 @default.
- W1970011172 creator A5012303330 @default.
- W1970011172 date "1995-11-07" @default.
- W1970011172 modified "2023-10-14" @default.
- W1970011172 title "The activation domain of GAL4 protein mediates cooperative promoter binding with general transcription factors in vivo." @default.
- W1970011172 cites W1560540551 @default.
- W1970011172 cites W1574489576 @default.
- W1970011172 cites W160239957 @default.
- W1970011172 cites W1623067816 @default.
- W1970011172 cites W165514063 @default.
- W1970011172 cites W1817418355 @default.
- W1970011172 cites W195998299 @default.
- W1970011172 cites W1965652496 @default.
- W1970011172 cites W1976978864 @default.
- W1970011172 cites W1982205026 @default.
- W1970011172 cites W1982669711 @default.
- W1970011172 cites W1986148754 @default.
- W1970011172 cites W1987270520 @default.
- W1970011172 cites W1988580221 @default.
- W1970011172 cites W1998671864 @default.
- W1970011172 cites W1999255494 @default.
- W1970011172 cites W2003002984 @default.
- W1970011172 cites W2006164030 @default.
- W1970011172 cites W2013083223 @default.
- W1970011172 cites W2013747720 @default.
- W1970011172 cites W2014841064 @default.
- W1970011172 cites W2015617558 @default.
- W1970011172 cites W2020484813 @default.
- W1970011172 cites W2027570258 @default.
- W1970011172 cites W2033777731 @default.
- W1970011172 cites W2034898151 @default.
- W1970011172 cites W2035194855 @default.
- W1970011172 cites W2038397261 @default.
- W1970011172 cites W2038580923 @default.
- W1970011172 cites W2053700118 @default.
- W1970011172 cites W2057050252 @default.
- W1970011172 cites W2057058623 @default.
- W1970011172 cites W2064194464 @default.
- W1970011172 cites W2065679706 @default.
- W1970011172 cites W2065867057 @default.
- W1970011172 cites W2066089226 @default.
- W1970011172 cites W2070398971 @default.
- W1970011172 cites W2079557259 @default.
- W1970011172 cites W2105014300 @default.
- W1970011172 cites W2114444630 @default.
- W1970011172 cites W2115073295 @default.
- W1970011172 cites W2119714784 @default.
- W1970011172 cites W2121013761 @default.
- W1970011172 cites W2130208743 @default.
- W1970011172 cites W2137508075 @default.
- W1970011172 cites W2140365848 @default.
- W1970011172 cites W2149920358 @default.
- W1970011172 cites W2155719842 @default.
- W1970011172 cites W2169142563 @default.
- W1970011172 cites W2187580260 @default.
- W1970011172 cites W2344014880 @default.
- W1970011172 cites W2528198080 @default.
- W1970011172 doi "https://doi.org/10.1073/pnas.92.23.10683" @default.
- W1970011172 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/40676" @default.
- W1970011172 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/7479865" @default.
- W1970011172 hasPublicationYear "1995" @default.
- W1970011172 type Work @default.
- W1970011172 sameAs 1970011172 @default.
- W1970011172 citedByCount "34" @default.
- W1970011172 countsByYear W19700111722012 @default.
- W1970011172 countsByYear W19700111722013 @default.
- W1970011172 countsByYear W19700111722015 @default.
- W1970011172 countsByYear W19700111722016 @default.
- W1970011172 countsByYear W19700111722022 @default.
- W1970011172 crossrefType "journal-article" @default.
- W1970011172 hasAuthorship W1970011172A5000290640 @default.
- W1970011172 hasAuthorship W1970011172A5012303330 @default.
- W1970011172 hasBestOaLocation W19700111722 @default.
- W1970011172 hasConcept C101762097 @default.
- W1970011172 hasConcept C104317684 @default.
- W1970011172 hasConcept C105208137 @default.
- W1970011172 hasConcept C107824862 @default.
- W1970011172 hasConcept C111936080 @default.
- W1970011172 hasConcept C132376346 @default.
- W1970011172 hasConcept C138885662 @default.
- W1970011172 hasConcept C144825837 @default.
- W1970011172 hasConcept C150194340 @default.
- W1970011172 hasConcept C153911025 @default.
- W1970011172 hasConcept C172768829 @default.
- W1970011172 hasConcept C179926584 @default.
- W1970011172 hasConcept C192245184 @default.
- W1970011172 hasConcept C25166345 @default.
- W1970011172 hasConcept C2776449523 @default.
- W1970011172 hasConcept C2780055153 @default.
- W1970011172 hasConcept C2909959438 @default.
- W1970011172 hasConcept C33987129 @default.
- W1970011172 hasConcept C41895202 @default.
- W1970011172 hasConcept C44498088 @default.
- W1970011172 hasConcept C55493867 @default.
- W1970011172 hasConcept C64350747 @default.
- W1970011172 hasConcept C65888428 @default.