Matches in SemOpenAlex for { <https://semopenalex.org/work/W1970016079> ?p ?o ?g. }
- W1970016079 endingPage "1847" @default.
- W1970016079 startingPage "1837" @default.
- W1970016079 abstract "Flavin-containing monooxygenases (FMOs), drug-metabolizing enzymes essential for the metabolism of endogenous biochemicals and foreign compounds, have been characterized in human (including FMO1-5 and FMO6P), but remain to be investigated in cynomolgus macaque. In this study, cDNAs of cynomolgus FMO1-5 and FMO6 were isolated and characterized. Amino acid sequences of cynomolgus FMO1-5, respectively, shared high sequence identities (94-98%) and were closely clustered in a phylogenetic tree, with human FMO1-5. Eight different transcripts, due to alternative splicing, were isolated for cynomolgus FMO6, which is highly identical (~96%) to human FMO6P. Among the 10 tissue types analyzed, cynomolgus FMO1, FMO2, FMO4, and FMO6 were most abundantly expressed in kidney, while cynomolgus FMO3 and FMO5 were most abundantly expressed in liver. In kidney and liver, the most abundantly expressed cynomolgus FMO genes were FMO1 and FMO3, respectively. Cynomolgus FMO1, FMO2, FMO3, and FMO5 metabolized benzydamine, and FMO1/FMO3 and FMO3 also metabolized methimazole and trimethylamine, respectively. Rates of benzydamine N-oxygenation (catalyzed by FMO3) varied (approximately 20-fold) among the 28 cynomolgus livers and were significantly correlated with FMO3 protein expression, indicating that the inter-animal variations in benzydamine N-oxygenation might be partly accounted for by the variable FMO3 expression. Cynomolgus FMO6 metabolized benzydamine only slightly, but minimal expression of FMO6 in all tissue precludes the importance of FMO6 in drug metabolism, unlike cynomolgus FMO1, FMO2, FMO3, and FMO5 which were all functional. Abundant expression of FMO1 and FMO3 in kidney and liver, respectively, suggest their importance in drug metabolism in cynomolgus macaque, similar to human." @default.
- W1970016079 created "2016-06-24" @default.
- W1970016079 creator A5044935635 @default.
- W1970016079 creator A5063924812 @default.
- W1970016079 creator A5078922881 @default.
- W1970016079 date "2013-06-01" @default.
- W1970016079 modified "2023-09-27" @default.
- W1970016079 title "Molecular and functional characterization of flavin-containing monooxygenases in cynomolgus macaque" @default.
- W1970016079 cites W1518683637 @default.
- W1970016079 cites W152513719 @default.
- W1970016079 cites W1565934703 @default.
- W1970016079 cites W1594693399 @default.
- W1970016079 cites W1606067601 @default.
- W1970016079 cites W1821482709 @default.
- W1970016079 cites W1966542879 @default.
- W1970016079 cites W1983231668 @default.
- W1970016079 cites W1993358760 @default.
- W1970016079 cites W1996617149 @default.
- W1970016079 cites W1999672815 @default.
- W1970016079 cites W2009373554 @default.
- W1970016079 cites W2018159164 @default.
- W1970016079 cites W2024669542 @default.
- W1970016079 cites W2027224416 @default.
- W1970016079 cites W2029181235 @default.
- W1970016079 cites W2037012505 @default.
- W1970016079 cites W2055666951 @default.
- W1970016079 cites W2057637319 @default.
- W1970016079 cites W2058667658 @default.
- W1970016079 cites W2060618580 @default.
- W1970016079 cites W2065359722 @default.
- W1970016079 cites W2065788138 @default.
- W1970016079 cites W2066878034 @default.
- W1970016079 cites W2068390361 @default.
- W1970016079 cites W2074034628 @default.
- W1970016079 cites W2081056949 @default.
- W1970016079 cites W2087820100 @default.
- W1970016079 cites W2100253760 @default.
- W1970016079 cites W2111899360 @default.
- W1970016079 cites W2112601493 @default.
- W1970016079 cites W2115016971 @default.
- W1970016079 cites W2117935121 @default.
- W1970016079 cites W2141360442 @default.
- W1970016079 cites W2145798500 @default.
- W1970016079 cites W2147834020 @default.
- W1970016079 cites W2148234649 @default.
- W1970016079 cites W2151469495 @default.
- W1970016079 cites W2151877060 @default.
- W1970016079 doi "https://doi.org/10.1016/j.bcp.2013.04.012" @default.
- W1970016079 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/23623750" @default.
- W1970016079 hasPublicationYear "2013" @default.
- W1970016079 type Work @default.
- W1970016079 sameAs 1970016079 @default.
- W1970016079 citedByCount "28" @default.
- W1970016079 countsByYear W19700160792014 @default.
- W1970016079 countsByYear W19700160792015 @default.
- W1970016079 countsByYear W19700160792016 @default.
- W1970016079 countsByYear W19700160792017 @default.
- W1970016079 countsByYear W19700160792018 @default.
- W1970016079 countsByYear W19700160792019 @default.
- W1970016079 countsByYear W19700160792020 @default.
- W1970016079 countsByYear W19700160792021 @default.
- W1970016079 countsByYear W19700160792022 @default.
- W1970016079 countsByYear W19700160792023 @default.
- W1970016079 crossrefType "journal-article" @default.
- W1970016079 hasAuthorship W1970016079A5044935635 @default.
- W1970016079 hasAuthorship W1970016079A5063924812 @default.
- W1970016079 hasAuthorship W1970016079A5078922881 @default.
- W1970016079 hasConcept C104317684 @default.
- W1970016079 hasConcept C13002179 @default.
- W1970016079 hasConcept C153911025 @default.
- W1970016079 hasConcept C185592680 @default.
- W1970016079 hasConcept C2776146729 @default.
- W1970016079 hasConcept C526171541 @default.
- W1970016079 hasConcept C54355233 @default.
- W1970016079 hasConcept C55493867 @default.
- W1970016079 hasConcept C62231903 @default.
- W1970016079 hasConcept C86803240 @default.
- W1970016079 hasConceptScore W1970016079C104317684 @default.
- W1970016079 hasConceptScore W1970016079C13002179 @default.
- W1970016079 hasConceptScore W1970016079C153911025 @default.
- W1970016079 hasConceptScore W1970016079C185592680 @default.
- W1970016079 hasConceptScore W1970016079C2776146729 @default.
- W1970016079 hasConceptScore W1970016079C526171541 @default.
- W1970016079 hasConceptScore W1970016079C54355233 @default.
- W1970016079 hasConceptScore W1970016079C55493867 @default.
- W1970016079 hasConceptScore W1970016079C62231903 @default.
- W1970016079 hasConceptScore W1970016079C86803240 @default.
- W1970016079 hasIssue "12" @default.
- W1970016079 hasLocation W19700160791 @default.
- W1970016079 hasLocation W19700160792 @default.
- W1970016079 hasOpenAccess W1970016079 @default.
- W1970016079 hasPrimaryLocation W19700160791 @default.
- W1970016079 hasRelatedWork W2033419819 @default.
- W1970016079 hasRelatedWork W2059623973 @default.
- W1970016079 hasRelatedWork W2103874617 @default.
- W1970016079 hasRelatedWork W2104797111 @default.
- W1970016079 hasRelatedWork W2118180263 @default.
- W1970016079 hasRelatedWork W2274026214 @default.