Matches in SemOpenAlex for { <https://semopenalex.org/work/W1970017530> ?p ?o ?g. }
- W1970017530 endingPage "375" @default.
- W1970017530 startingPage "375" @default.
- W1970017530 abstract "Equine recurrent uveitis (ERU) is an incurable disease affecting the inner eye that leads to blindness, through activated T cells that pass the blood-retinal barrier and destroy the retina. Serum markers are a desirable choice for monitoring development of disease, as serum is easy accessible and the markers could serve to predict the beginning of disease or an imminent relapse.In this study, serum proteomes (depleted of high-abundance serum proteins) of horses with ERU and healthy controls were compared with the 2-D DIGE (two-dimensional gel electrophoresis) technique to identify differentially expressed proteins. The expression pattern of a candidate protein in retina and vitreous was validated by Western blots and immunohistochemistry.Ten differentially expressed proteins could be identified by mass spectrometry (MALDI-TOF/TOF). Five proteins--IgM, IgG4 hc, serotransferrin, alpha-2HS-glycoprotein, and complement factor B--were upregulated in the uveitic state, whereas the five proteins albumin, apolipoprotein A-IV and H, IgG5 hc, and high-molecular-weight kininogen (HK) showed a significantly lower expression in sera of uveitis cases. Of interest, kininogen was significantly upregulated in the target tissues vitreous and retina. HK is a plasma protein with multiple physiological functions, with an important role in inflammation and promoting neovascularization. Most interesting is the as of yet unaddressed association of HK with uveitis. Immunohistochemistry showed coexpression of kininogen and VEGF in inflamed eyes.Since neovascularization plays a major role in the pathogenesis of uveitis, the identification of a proangiogenic factor in the retina presents an important finding and may contribute to elucidating the pathogenesis of uveitis." @default.
- W1970017530 created "2016-06-24" @default.
- W1970017530 creator A5009152753 @default.
- W1970017530 creator A5025441654 @default.
- W1970017530 creator A5045991073 @default.
- W1970017530 creator A5053204551 @default.
- W1970017530 creator A5060863472 @default.
- W1970017530 creator A5086062131 @default.
- W1970017530 creator A5089003025 @default.
- W1970017530 creator A5091913003 @default.
- W1970017530 date "2010-01-01" @default.
- W1970017530 modified "2023-09-27" @default.
- W1970017530 title "Kininogen in Autoimmune Uveitis: Decrease in Peripheral Blood Stream versus Increase in Target Tissue" @default.
- W1970017530 cites W1228621099 @default.
- W1970017530 cites W1255511787 @default.
- W1970017530 cites W1486274120 @default.
- W1970017530 cites W1576091094 @default.
- W1970017530 cites W1605392416 @default.
- W1970017530 cites W1607236619 @default.
- W1970017530 cites W1964474770 @default.
- W1970017530 cites W1973583261 @default.
- W1970017530 cites W1973996978 @default.
- W1970017530 cites W1977871074 @default.
- W1970017530 cites W1980219722 @default.
- W1970017530 cites W1985947600 @default.
- W1970017530 cites W2002396315 @default.
- W1970017530 cites W2007709883 @default.
- W1970017530 cites W2012156591 @default.
- W1970017530 cites W2013256337 @default.
- W1970017530 cites W2019661792 @default.
- W1970017530 cites W2024181247 @default.
- W1970017530 cites W2029187903 @default.
- W1970017530 cites W2029935265 @default.
- W1970017530 cites W2031784696 @default.
- W1970017530 cites W2033402026 @default.
- W1970017530 cites W2037973850 @default.
- W1970017530 cites W2064577212 @default.
- W1970017530 cites W2070635810 @default.
- W1970017530 cites W2072910044 @default.
- W1970017530 cites W2073158216 @default.
- W1970017530 cites W2073851077 @default.
- W1970017530 cites W2075624081 @default.
- W1970017530 cites W2078678101 @default.
- W1970017530 cites W2079655276 @default.
- W1970017530 cites W2088090688 @default.
- W1970017530 cites W2101812962 @default.
- W1970017530 cites W2102686649 @default.
- W1970017530 cites W2115397673 @default.
- W1970017530 cites W2116153242 @default.
- W1970017530 cites W2125468516 @default.
- W1970017530 cites W2126667414 @default.
- W1970017530 cites W2133265333 @default.
- W1970017530 cites W2135457409 @default.
- W1970017530 cites W2144901303 @default.
- W1970017530 cites W2145815056 @default.
- W1970017530 cites W2148232659 @default.
- W1970017530 cites W2157900496 @default.
- W1970017530 cites W2162928156 @default.
- W1970017530 cites W2166884187 @default.
- W1970017530 cites W2172116519 @default.
- W1970017530 cites W2471467296 @default.
- W1970017530 cites W315197452 @default.
- W1970017530 cites W94191212 @default.
- W1970017530 doi "https://doi.org/10.1167/iovs.09-4094" @default.
- W1970017530 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/19696180" @default.
- W1970017530 hasPublicationYear "2010" @default.
- W1970017530 type Work @default.
- W1970017530 sameAs 1970017530 @default.
- W1970017530 citedByCount "18" @default.
- W1970017530 countsByYear W19700175302012 @default.
- W1970017530 countsByYear W19700175302014 @default.
- W1970017530 countsByYear W19700175302015 @default.
- W1970017530 countsByYear W19700175302016 @default.
- W1970017530 countsByYear W19700175302017 @default.
- W1970017530 countsByYear W19700175302018 @default.
- W1970017530 countsByYear W19700175302020 @default.
- W1970017530 countsByYear W19700175302021 @default.
- W1970017530 countsByYear W19700175302022 @default.
- W1970017530 crossrefType "journal-article" @default.
- W1970017530 hasAuthorship W1970017530A5009152753 @default.
- W1970017530 hasAuthorship W1970017530A5025441654 @default.
- W1970017530 hasAuthorship W1970017530A5045991073 @default.
- W1970017530 hasAuthorship W1970017530A5053204551 @default.
- W1970017530 hasAuthorship W1970017530A5060863472 @default.
- W1970017530 hasAuthorship W1970017530A5086062131 @default.
- W1970017530 hasAuthorship W1970017530A5089003025 @default.
- W1970017530 hasAuthorship W1970017530A5091913003 @default.
- W1970017530 hasConcept C104317684 @default.
- W1970017530 hasConcept C126322002 @default.
- W1970017530 hasConcept C142724271 @default.
- W1970017530 hasConcept C169760540 @default.
- W1970017530 hasConcept C203014093 @default.
- W1970017530 hasConcept C204232928 @default.
- W1970017530 hasConcept C2776194053 @default.
- W1970017530 hasConcept C2776415932 @default.
- W1970017530 hasConcept C2777093970 @default.
- W1970017530 hasConcept C2778271429 @default.
- W1970017530 hasConcept C2780394083 @default.