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- W1970032446 abstract "Novel 5-aryl indanones, inden-1-one oximes, and inden-1-ols were synthesized and evaluated as progesterone receptor (PR) modulators using the T47D cell alkaline phosphatase assay. Both PR agonists and antagonists were achieved with appropriate 3- and 5-substitution from indanones and inden-1-ols while inden-1-one oximes provided only PR antagonists. Several compounds such as 10 and 11 demonstrated potent in vitro PR agonist potency similar to that of steroidal progesterone (1). In addition, a number of compounds (e.g., 12, 13, 17, 18) showed potent PR antagonist activity indicating the indanones and derivatives are promising PR modulator templates." @default.
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- W1970032446 date "2009-12-01" @default.
- W1970032446 modified "2023-09-26" @default.
- W1970032446 title "5-Aryl indanones and derivatives as non-steroidal progesterone receptor modulators" @default.
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- W1970032446 doi "https://doi.org/10.1016/j.bmcl.2009.10.008" @default.
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