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• W1970033716 abstract "A new series of linear dimeric compounds mimicking naturally occurring annonaceous acetogenins have been synthesized by bivalent analogue design, and their cytotoxicities have been evaluated against the growth of cancer cells by MTT method. Most of these compounds show selective action favored to human cancer cell lines over normal cell lines, and compound 9 with bis-terminal benzoquinone functionality exhibits an IC50 = 0.40 μM against MCF7 cell lines. This work mentions that appropriate conformational constraints might be a useful optimizing tool for this unique class of anticancer compounds." @default.
• W1970033716 created "2016-06-24" @default.
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• W1970033716 date "2011-06-01" @default.
• W1970033716 modified "2023-10-11" @default.
• W1970033716 title "Design, synthesis of symmetrical bivalent mimetics of annonaceous acetogenins and their cytotoxicities" @default.
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• W1970033716 doi "https://doi.org/10.1016/j.bmcl.2011.04.095" @default.
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