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- W1970035535 abstract "Height and body mass index (BMI) have high heritability in most studies. High BMI and reduced height are well-recognized as important risk factors for a number of cardiovascular diseases. We investigated these phenotypes in African American families originally ascertained for studies of linkage with type 2 diabetes using self-reported height and weight. We conducted a genome wide scan in 221 families containing 580 individuals and 672 relative pairs of African American descent. Estimates of heritability and support for linkage were assessed by genetic variance component analyses using SOLAR software. The estimated heritabilities for height and BMI were 0.43 and 0.64, respectively. We have identified major loci contributing to variation in height on chromosomes 15 (LOD = 2.61 at 35 cM, p = 0.0004), 3 (LOD = 1.82 at 84 cM, p = 0.0029), 8 (LOD = 1.92 at 135 cM, p = 0.0024) and 17 (LOD = 1.70 at 110 cM, p = 0.0044). A broad region on chromosome 4 supported evidence of linkage to variation in BMI, with the highest LOD = 2.66 at 168 cM (p = 0.0005). Two height loci and two BMI loci appear to confirm the existence of quantitative trait loci previously identified by other studies, providing important replicative data to allow further resolution of linkage regions suitable for positional cloning of these cardiovascular disease risk loci." @default.
- W1970035535 created "2016-06-24" @default.
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- W1970035535 date "2005-09-01" @default.
- W1970035535 modified "2023-10-16" @default.
- W1970035535 title "Loci Contributing to Adult Height and Body Mass Index in African American Families Ascertained for Type 2 Diabetes" @default.
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- W1970035535 cites W1976741643 @default.
- W1970035535 cites W1978136073 @default.
- W1970035535 cites W1978375067 @default.
- W1970035535 cites W1978980810 @default.
- W1970035535 cites W1983985489 @default.
- W1970035535 cites W1984217495 @default.
- W1970035535 cites W1993864641 @default.
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- W1970035535 cites W1997254172 @default.
- W1970035535 cites W1997919708 @default.
- W1970035535 cites W1998880332 @default.
- W1970035535 cites W1999104632 @default.
- W1970035535 cites W2010117564 @default.
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- W1970035535 cites W2020052660 @default.
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- W1970035535 doi "https://doi.org/10.1046/j.1529-8817.2005.00176.x" @default.
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