Matches in SemOpenAlex for { <https://semopenalex.org/work/W1970036281> ?p ?o ?g. }
- W1970036281 endingPage "13291" @default.
- W1970036281 startingPage "13286" @default.
- W1970036281 abstract "In mammalian muscle a postnatal switch in functional properties of neuromuscular transmission occurs when miniature end plate currents become shorter and the conductance and Ca2+ permeability of end plate channels increases. These changes are due to replacement during early neonatal development of the gamma-subunit of the fetal acetylcholine receptor (AChR) by the epsilon-subunit. The long-term functional consequences of this switch for neuromuscular transmission and motor behavior of the animal remained elusive. We report that deletion of the epsilon-subunit gene caused in homozygous mutant mice the persistence of gamma-subunit gene expression in juvenile and adult animals. Neuromuscular transmission in these animals is based on fetal type AChRs present in the end plate at reduced density. Impaired neuromuscular transmission, progressive muscle weakness, and atrophy caused premature death 2 to 3 months after birth. The results demonstrate that postnatal incorporation into the end plate of epsilon-subunit containing AChRs is essential for normal development of skeletal muscle." @default.
- W1970036281 created "2016-06-24" @default.
- W1970036281 creator A5010665281 @default.
- W1970036281 creator A5012092193 @default.
- W1970036281 creator A5026835443 @default.
- W1970036281 creator A5045434275 @default.
- W1970036281 creator A5047299989 @default.
- W1970036281 creator A5074956078 @default.
- W1970036281 creator A5076549033 @default.
- W1970036281 creator A5082041058 @default.
- W1970036281 date "1996-11-12" @default.
- W1970036281 modified "2023-10-18" @default.
- W1970036281 title "Acetylcholine receptor ɛ-subunit deletion causes muscle weakness and atrophy in juvenile and adult mice" @default.
- W1970036281 cites W1536554840 @default.
- W1970036281 cites W1676813425 @default.
- W1970036281 cites W1951597003 @default.
- W1970036281 cites W1964800013 @default.
- W1970036281 cites W1967046155 @default.
- W1970036281 cites W1971880089 @default.
- W1970036281 cites W1977106724 @default.
- W1970036281 cites W1984073192 @default.
- W1970036281 cites W1990907625 @default.
- W1970036281 cites W1993085665 @default.
- W1970036281 cites W1997511216 @default.
- W1970036281 cites W1997531619 @default.
- W1970036281 cites W1997551871 @default.
- W1970036281 cites W2003108544 @default.
- W1970036281 cites W2009667219 @default.
- W1970036281 cites W2015426350 @default.
- W1970036281 cites W2026155884 @default.
- W1970036281 cites W2027991308 @default.
- W1970036281 cites W2033009158 @default.
- W1970036281 cites W2047197571 @default.
- W1970036281 cites W2056243137 @default.
- W1970036281 cites W2070159820 @default.
- W1970036281 cites W2076657715 @default.
- W1970036281 cites W2079958883 @default.
- W1970036281 cites W2091723337 @default.
- W1970036281 cites W2097172944 @default.
- W1970036281 cites W2134812217 @default.
- W1970036281 cites W2160198224 @default.
- W1970036281 cites W2163548105 @default.
- W1970036281 cites W2405622496 @default.
- W1970036281 cites W4294216491 @default.
- W1970036281 doi "https://doi.org/10.1073/pnas.93.23.13286" @default.
- W1970036281 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/24085" @default.
- W1970036281 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/8917583" @default.
- W1970036281 hasPublicationYear "1996" @default.
- W1970036281 type Work @default.
- W1970036281 sameAs 1970036281 @default.
- W1970036281 citedByCount "102" @default.
- W1970036281 countsByYear W19700362812012 @default.
- W1970036281 countsByYear W19700362812013 @default.
- W1970036281 countsByYear W19700362812014 @default.
- W1970036281 countsByYear W19700362812015 @default.
- W1970036281 countsByYear W19700362812016 @default.
- W1970036281 countsByYear W19700362812017 @default.
- W1970036281 countsByYear W19700362812018 @default.
- W1970036281 countsByYear W19700362812019 @default.
- W1970036281 countsByYear W19700362812020 @default.
- W1970036281 countsByYear W19700362812021 @default.
- W1970036281 crossrefType "journal-article" @default.
- W1970036281 hasAuthorship W1970036281A5010665281 @default.
- W1970036281 hasAuthorship W1970036281A5012092193 @default.
- W1970036281 hasAuthorship W1970036281A5026835443 @default.
- W1970036281 hasAuthorship W1970036281A5045434275 @default.
- W1970036281 hasAuthorship W1970036281A5047299989 @default.
- W1970036281 hasAuthorship W1970036281A5074956078 @default.
- W1970036281 hasAuthorship W1970036281A5076549033 @default.
- W1970036281 hasAuthorship W1970036281A5082041058 @default.
- W1970036281 hasBestOaLocation W19700362811 @default.
- W1970036281 hasConcept C104292427 @default.
- W1970036281 hasConcept C104317684 @default.
- W1970036281 hasConcept C105702510 @default.
- W1970036281 hasConcept C126322002 @default.
- W1970036281 hasConcept C134018914 @default.
- W1970036281 hasConcept C169760540 @default.
- W1970036281 hasConcept C170493617 @default.
- W1970036281 hasConcept C2776418732 @default.
- W1970036281 hasConcept C2777240379 @default.
- W1970036281 hasConcept C2779959927 @default.
- W1970036281 hasConcept C2781172350 @default.
- W1970036281 hasConcept C2910882050 @default.
- W1970036281 hasConcept C3020341438 @default.
- W1970036281 hasConcept C54355233 @default.
- W1970036281 hasConcept C71924100 @default.
- W1970036281 hasConcept C80161118 @default.
- W1970036281 hasConcept C86803240 @default.
- W1970036281 hasConcept C95444343 @default.
- W1970036281 hasConceptScore W1970036281C104292427 @default.
- W1970036281 hasConceptScore W1970036281C104317684 @default.
- W1970036281 hasConceptScore W1970036281C105702510 @default.
- W1970036281 hasConceptScore W1970036281C126322002 @default.
- W1970036281 hasConceptScore W1970036281C134018914 @default.
- W1970036281 hasConceptScore W1970036281C169760540 @default.
- W1970036281 hasConceptScore W1970036281C170493617 @default.
- W1970036281 hasConceptScore W1970036281C2776418732 @default.
- W1970036281 hasConceptScore W1970036281C2777240379 @default.