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• W1970046036 startingPage "11" @default.
• W1970046036 abstract "Axonal degeneration plays an important role in the accumulation of disability in patients with multiple sclerosis (MS). Pathological studies have demonstrated axonal damage, particularly in areas of acute inflammation and demyelination, and in chronic lesions. Axonal loss and its progression, which is associated with neurological disability, has also been demonstrated by magnetic resonance imaging (MRI) studies. The mechanisms of axonal loss are uncertain, but may involve axonal degeneration secondary to demyelination, or damage to the axonal cytoskeleton. Inflammatory mediators, including cytokines and proteolytic enzymes may contribute to axonal damage, as may nitric oxide. Axonal destruction may also be due to immune attack directed at axonal components. The realisation that axonal degeneration is a fundamental component of MS that may occur early in the disease course should alter the approach to management and open avenues to a more targeted immunotherapy aimed at reducing the progression of disability." @default.
• W1970046036 created "2016-06-24" @default.
• W1970046036 creator A5051859650 @default.
• W1970046036 creator A5063711884 @default.
• W1970046036 date "1999-11-01" @default.
• W1970046036 modified "2023-10-18" @default.
• W1970046036 title "Axonal degeneration in the pathogenesis of multiple sclerosis" @default.
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• W1970046036 doi "https://doi.org/10.1016/s0022-510x(99)00178-1" @default.
• W1970046036 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/10540030" @default.
• W1970046036 hasPublicationYear "1999" @default.
• W1970046036 type Work @default.

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