FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1970049852> ?p ?o ?g. }

• W1970049852 endingPage "903" @default.
• W1970049852 startingPage "897" @default.
• W1970049852 abstract "Cytochrome c oxidase is a membrane-bound enzyme, which catalyses the one-electron oxidation of four molecules of cytochrome c and the four-electron reduction of O2 to water. Electron transfer through the enzyme is coupled to proton pumping across the membrane. Protons that are pumped as well as those that are used for O2 reduction are transferred though a specific intraprotein (D) pathway. Results from earlier studies have shown that replacement of residue Asn139 by an Asp, at the beginning of the D pathway, results in blocking proton pumping without slowing uptake of substrate protons used for O2 reduction. Furthermore, introduction of the acidic residue results in an increase of the apparent pKa of E286, an internal proton donor to the catalytic site, from 9.4 to ~ 11. In this study we have investigated intramolecular electron and proton transfer in a mutant cytochrome c oxidase in which a neutral residue, Thr, was introduced at the 139 site. The mutation results in uncoupling of proton pumping from O2 reduction, but a decrease in the apparent pKa of E286 from 9.4 to 7.6. The data provide insights into the mechanism by which cytochrome c oxidase pumps protons and the structural elements involved in this process." @default.
• W1970049852 created "2016-06-24" @default.
• W1970049852 creator A5008855880 @default.
• W1970049852 creator A5021155040 @default.
• W1970049852 creator A5056829720 @default.
• W1970049852 creator A5078059871 @default.
• W1970049852 creator A5086677414 @default.
• W1970049852 date "2008-07-01" @default.
• W1970049852 modified "2023-10-01" @default.
• W1970049852 title "Impaired proton pumping in cytochrome c oxidase upon structural alteration of the D pathway" @default.
• W1970049852 cites W1963961936 @default.
• W1970049852 cites W1967888351 @default.
• W1970049852 cites W1970143646 @default.
• W1970049852 cites W1976736573 @default.
• W1970049852 cites W1977467280 @default.
• W1970049852 cites W1982722445 @default.
• W1970049852 cites W1985950029 @default.
• W1970049852 cites W1990909752 @default.
• W1970049852 cites W1994886687 @default.
• W1970049852 cites W1998969789 @default.
• W1970049852 cites W1999335754 @default.
• W1970049852 cites W2001806196 @default.
• W1970049852 cites W2009014524 @default.
• W1970049852 cites W2013705610 @default.
• W1970049852 cites W2014370128 @default.
• W1970049852 cites W2015133195 @default.
• W1970049852 cites W2018629174 @default.
• W1970049852 cites W2020904305 @default.
• W1970049852 cites W2022144901 @default.
• W1970049852 cites W2023257111 @default.
• W1970049852 cites W2023485451 @default.
• W1970049852 cites W2023818693 @default.
• W1970049852 cites W2025088494 @default.
• W1970049852 cites W2027857789 @default.
• W1970049852 cites W2027864924 @default.
• W1970049852 cites W2029217278 @default.
• W1970049852 cites W2029667189 @default.
• W1970049852 cites W2035520386 @default.
• W1970049852 cites W2038361800 @default.
• W1970049852 cites W2039159880 @default.
• W1970049852 cites W2044509619 @default.
• W1970049852 cites W2047561022 @default.
• W1970049852 cites W2054262012 @default.
• W1970049852 cites W2056468967 @default.
• W1970049852 cites W2057286919 @default.
• W1970049852 cites W2058380052 @default.
• W1970049852 cites W2060897601 @default.
• W1970049852 cites W2061525480 @default.
• W1970049852 cites W2061670528 @default.
• W1970049852 cites W2068407991 @default.
• W1970049852 cites W2069925074 @default.
• W1970049852 cites W2074187025 @default.
• W1970049852 cites W2074256604 @default.
• W1970049852 cites W2085800822 @default.
• W1970049852 cites W2086725737 @default.
• W1970049852 cites W2089444699 @default.
• W1970049852 cites W2108038276 @default.
• W1970049852 cites W2129594976 @default.
• W1970049852 cites W2135271259 @default.
• W1970049852 cites W2157859603 @default.
• W1970049852 cites W2327992616 @default.
• W1970049852 cites W2614850441 @default.
• W1970049852 cites W41182407 @default.
• W1970049852 doi "https://doi.org/10.1016/j.bbabio.2008.04.013" @default.
• W1970049852 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4309377" @default.
• W1970049852 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/18457654" @default.
• W1970049852 hasPublicationYear "2008" @default.
• W1970049852 type Work @default.
• W1970049852 sameAs 1970049852 @default.
• W1970049852 citedByCount "46" @default.
• W1970049852 countsByYear W19700498522012 @default.
• W1970049852 countsByYear W19700498522013 @default.
• W1970049852 countsByYear W19700498522014 @default.
• W1970049852 countsByYear W19700498522015 @default.
• W1970049852 countsByYear W19700498522016 @default.
• W1970049852 countsByYear W19700498522017 @default.
• W1970049852 countsByYear W19700498522018 @default.
• W1970049852 countsByYear W19700498522019 @default.
• W1970049852 countsByYear W19700498522020 @default.
• W1970049852 countsByYear W19700498522021 @default.
• W1970049852 crossrefType "journal-article" @default.
• W1970049852 hasAuthorship W1970049852A5008855880 @default.
• W1970049852 hasAuthorship W1970049852A5021155040 @default.
• W1970049852 hasAuthorship W1970049852A5056829720 @default.
• W1970049852 hasAuthorship W1970049852A5078059871 @default.
• W1970049852 hasAuthorship W1970049852A5086677414 @default.
• W1970049852 hasBestOaLocation W19700498521 @default.
• W1970049852 hasConcept C121332964 @default.
• W1970049852 hasConcept C123249941 @default.
• W1970049852 hasConcept C123669783 @default.
• W1970049852 hasConcept C12554922 @default.
• W1970049852 hasConcept C181199279 @default.
• W1970049852 hasConcept C185592680 @default.
• W1970049852 hasConcept C24840226 @default.
• W1970049852 hasConcept C2780768313 @default.
• W1970049852 hasConcept C28859421 @default.
• W1970049852 hasConcept C29311851 @default.
• W1970049852 hasConcept C38485361 @default.

• next