FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1970050903> ?p ?o ?g. }

• W1970050903 endingPage "1005" @default.
• W1970050903 startingPage "1000" @default.
• W1970050903 abstract "Human leukocyte antigen–G (HLA-G) is a nonclassical tolerogenic molecule that can be expressed either as membrane bound (HLA-G1) or secreted (HLA-G5) isoforms. Upregulation of HLA-G1 or HLA-G5 expression by tumor cells constitutes an efficient way to escape from antitumoral immune responses. The inhibitory role of HLA-G1 on NK cell cytotoxicity is well characterized; however, that of the HLA-G5 isoform secreted by tumor is poorly understood. Our results indicate that the HLA-G5 isoform secreted by M8 melanoma cells is able to protect them from natural killer leukemia cell line (NKL) cytotoxicity. Analysis of NKL/M8-HLA-G5 conjugates by confocal microscopy demonstrates that the inhibition of NKL cytotoxic activity resulted from an impairment of NKL actin reorganization and perforin granules polarization toward M8-HLA-G5 target cell. This study also indicates that HLA-G5 soluble isoform remains evenly distributed in the cytoplasm of M8-HLA-G5 conjugated to NKL cells, suggesting that HLA-G5 does not require to polarize toward effector cell to induce efficient inhibition. These results highlight the inhibitory mechanisms mediated through HLA-G5 leading to tumor escape from NK cell cytotoxicity." @default.
• W1970050903 created "2016-06-24" @default.
• W1970050903 creator A5041378929 @default.
• W1970050903 creator A5044429148 @default.
• W1970050903 creator A5054987840 @default.
• W1970050903 creator A5055543596 @default.
• W1970050903 creator A5063231825 @default.
• W1970050903 creator A5068650342 @default.
• W1970050903 creator A5085612159 @default.
• W1970050903 date "2009-12-01" @default.
• W1970050903 modified "2023-10-11" @default.
• W1970050903 title "Human melanoma cell secreting human leukocyte antigen–G5 inhibit natural killer cell cytotoxicity by impairing lytic granules polarization toward target cell" @default.
• W1970050903 cites W1487795020 @default.
• W1970050903 cites W1506551612 @default.
• W1970050903 cites W1585977107 @default.
• W1970050903 cites W1979253523 @default.
• W1970050903 cites W1982946090 @default.
• W1970050903 cites W1992208836 @default.
• W1970050903 cites W1997922708 @default.
• W1970050903 cites W2008271458 @default.
• W1970050903 cites W2030021944 @default.
• W1970050903 cites W2030381568 @default.
• W1970050903 cites W2052997719 @default.
• W1970050903 cites W2058963746 @default.
• W1970050903 cites W2061826103 @default.
• W1970050903 cites W2064664419 @default.
• W1970050903 cites W2070551124 @default.
• W1970050903 cites W2073300038 @default.
• W1970050903 cites W2079136653 @default.
• W1970050903 cites W2090887099 @default.
• W1970050903 cites W2094861927 @default.
• W1970050903 cites W2110435881 @default.
• W1970050903 cites W2115158275 @default.
• W1970050903 cites W2117918558 @default.
• W1970050903 cites W2118600609 @default.
• W1970050903 cites W2150054315 @default.
• W1970050903 cites W2153385228 @default.
• W1970050903 cites W2171709048 @default.
• W1970050903 doi "https://doi.org/10.1016/j.humimm.2009.07.019" @default.
• W1970050903 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/19654030" @default.
• W1970050903 hasPublicationYear "2009" @default.
• W1970050903 type Work @default.
• W1970050903 sameAs 1970050903 @default.
• W1970050903 citedByCount "27" @default.
• W1970050903 countsByYear W19700509032012 @default.
• W1970050903 countsByYear W19700509032013 @default.
• W1970050903 countsByYear W19700509032014 @default.
• W1970050903 countsByYear W19700509032015 @default.
• W1970050903 countsByYear W19700509032016 @default.
• W1970050903 countsByYear W19700509032017 @default.
• W1970050903 countsByYear W19700509032019 @default.
• W1970050903 countsByYear W19700509032020 @default.
• W1970050903 countsByYear W19700509032021 @default.
• W1970050903 countsByYear W19700509032022 @default.
• W1970050903 crossrefType "journal-article" @default.
• W1970050903 hasAuthorship W1970050903A5041378929 @default.
• W1970050903 hasAuthorship W1970050903A5044429148 @default.
• W1970050903 hasAuthorship W1970050903A5054987840 @default.
• W1970050903 hasAuthorship W1970050903A5055543596 @default.
• W1970050903 hasAuthorship W1970050903A5063231825 @default.
• W1970050903 hasAuthorship W1970050903A5068650342 @default.
• W1970050903 hasAuthorship W1970050903A5085612159 @default.
• W1970050903 hasConcept C109316439 @default.
• W1970050903 hasConcept C129374314 @default.
• W1970050903 hasConcept C147483822 @default.
• W1970050903 hasConcept C1491633281 @default.
• W1970050903 hasConcept C153911025 @default.
• W1970050903 hasConcept C154317977 @default.
• W1970050903 hasConcept C167672396 @default.
• W1970050903 hasConcept C185592680 @default.
• W1970050903 hasConcept C188280979 @default.
• W1970050903 hasConcept C202751555 @default.
• W1970050903 hasConcept C203014093 @default.
• W1970050903 hasConcept C2776062744 @default.
• W1970050903 hasConcept C2778102761 @default.
• W1970050903 hasConcept C28651165 @default.
• W1970050903 hasConcept C40677261 @default.
• W1970050903 hasConcept C54355233 @default.
• W1970050903 hasConcept C55493867 @default.
• W1970050903 hasConcept C81885089 @default.
• W1970050903 hasConcept C86803240 @default.
• W1970050903 hasConcept C95444343 @default.
• W1970050903 hasConceptScore W1970050903C109316439 @default.
• W1970050903 hasConceptScore W1970050903C129374314 @default.
• W1970050903 hasConceptScore W1970050903C147483822 @default.
• W1970050903 hasConceptScore W1970050903C1491633281 @default.
• W1970050903 hasConceptScore W1970050903C153911025 @default.
• W1970050903 hasConceptScore W1970050903C154317977 @default.
• W1970050903 hasConceptScore W1970050903C167672396 @default.
• W1970050903 hasConceptScore W1970050903C185592680 @default.
• W1970050903 hasConceptScore W1970050903C188280979 @default.
• W1970050903 hasConceptScore W1970050903C202751555 @default.
• W1970050903 hasConceptScore W1970050903C203014093 @default.
• W1970050903 hasConceptScore W1970050903C2776062744 @default.
• W1970050903 hasConceptScore W1970050903C2778102761 @default.
• W1970050903 hasConceptScore W1970050903C28651165 @default.
• W1970050903 hasConceptScore W1970050903C40677261 @default.
• W1970050903 hasConceptScore W1970050903C54355233 @default.

• next