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- W1970051514 abstract "This study evaluates effects of anesthesia on 18F-FDG (FDG) uptake in mouse brain and heart to establish the basic conditions of small animal PET imaging. Prior to FDG injection, 12 mice were anesthetized with isoflurane gas; 11 mice were anesthetized with an intraperitoneal injection of a ketamine/xylazine mixture; and 11 mice were awake. In isoflurane and ketamine/xylazine conditions, FDG brain uptake (%ID/g) was significantly lower than in controls. Conversely, in the isoflurane condition, %ID/g in heart was significantly higher than in controls, whereas heart uptake in ketamine/xylazine mice was significantly lower. Results suggest that anesthesia impedes FDG uptake in mouse brain and affects FDG uptake in heart; however, the effects in the brain and heart differ depending on the type of anesthesia used." @default.
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- W1970051514 date "2004-02-01" @default.
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- W1970051514 title "Evaluation of anesthesia effects on [18F]FDG uptake in mouse brain and heart using small animal PET" @default.
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- W1970051514 doi "https://doi.org/10.1016/s0969-8051(03)00124-0" @default.
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