Matches in SemOpenAlex for { <https://semopenalex.org/work/W1970053105> ?p ?o ?g. }
Showing items 1 to 86 of
86
with 100 items per page.
- W1970053105 endingPage "516" @default.
- W1970053105 startingPage "511" @default.
- W1970053105 abstract "A longitudinal study of the replication capacity of HIV strains isolated from 18 patients failing highly active antiretroviral therapy (HAART) was undertaken at the time of genotypic guided change of therapy and after 12 months. Patients were divided in two groups according to the response to therapy: immune responders (12 patients with immune recovery defined as having more than 100 CD4 cells compared to baseline value), and failing patients (six patients without immune recovery). At enrolment no significant difference in terms of CD4 cell count and HIV plasma viremia was detected between the two groups. One year after change of therapy, all patients experienced a decrease in the replication capacity of HIV strains. The HIV replication capacity of the failing and of immune-responder patients decreased from 60% (range 14–96%) to 26.4% (range 0.4–74.5) and from 46.8% (range 15–98%) to 3.6% (range 0.1–26.8%), respectively. At month 12, the difference of HIV replication capacity between the two groups reached a statistical significance (P < 0.03). After the change of therapy, an increase in the number of drug resistance mutations in the protease gene was detected in both groups with a higher prevalence of M36I mutation in immune responders. The HIV strains of patients failing HAART showed a progressive impaired replication capacity. The degree of the impairment in viral replication correlated with the viro-immunological discordant response to HAART and with the acquisition of new drug resistant mutations in the protease gene. In patients failing HAART, the impaired replication capacity of HIV strains could justify the persistence of an immune recovery. J. Med. Virol. 72:511–516, 2004. © 2004 Wiley-Liss, Inc." @default.
- W1970053105 created "2016-06-24" @default.
- W1970053105 creator A5009952922 @default.
- W1970053105 creator A5013283434 @default.
- W1970053105 creator A5020412439 @default.
- W1970053105 creator A5027991189 @default.
- W1970053105 creator A5047826305 @default.
- W1970053105 creator A5064623739 @default.
- W1970053105 creator A5066246677 @default.
- W1970053105 creator A5075572192 @default.
- W1970053105 creator A5089927866 @default.
- W1970053105 creator A5064159036 @default.
- W1970053105 date "2004-02-13" @default.
- W1970053105 modified "2023-09-26" @default.
- W1970053105 title "Decrease of replicative capacity of HIV isolates after genotypic guided change of therapy" @default.
- W1970053105 doi "https://doi.org/10.1002/jmv.20030" @default.
- W1970053105 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/14981751" @default.
- W1970053105 hasPublicationYear "2004" @default.
- W1970053105 type Work @default.
- W1970053105 sameAs 1970053105 @default.
- W1970053105 citedByCount "7" @default.
- W1970053105 crossrefType "journal-article" @default.
- W1970053105 hasAuthorship W1970053105A5009952922 @default.
- W1970053105 hasAuthorship W1970053105A5013283434 @default.
- W1970053105 hasAuthorship W1970053105A5020412439 @default.
- W1970053105 hasAuthorship W1970053105A5027991189 @default.
- W1970053105 hasAuthorship W1970053105A5047826305 @default.
- W1970053105 hasAuthorship W1970053105A5064159036 @default.
- W1970053105 hasAuthorship W1970053105A5064623739 @default.
- W1970053105 hasAuthorship W1970053105A5066246677 @default.
- W1970053105 hasAuthorship W1970053105A5075572192 @default.
- W1970053105 hasAuthorship W1970053105A5089927866 @default.
- W1970053105 hasConcept C104317684 @default.
- W1970053105 hasConcept C135763542 @default.
- W1970053105 hasConcept C140704245 @default.
- W1970053105 hasConcept C142462285 @default.
- W1970053105 hasConcept C159047783 @default.
- W1970053105 hasConcept C203014093 @default.
- W1970053105 hasConcept C2522874641 @default.
- W1970053105 hasConcept C2776185481 @default.
- W1970053105 hasConcept C2779690655 @default.
- W1970053105 hasConcept C2780727368 @default.
- W1970053105 hasConcept C2781143361 @default.
- W1970053105 hasConcept C2993143319 @default.
- W1970053105 hasConcept C54355233 @default.
- W1970053105 hasConcept C71924100 @default.
- W1970053105 hasConcept C86803240 @default.
- W1970053105 hasConcept C8891405 @default.
- W1970053105 hasConceptScore W1970053105C104317684 @default.
- W1970053105 hasConceptScore W1970053105C135763542 @default.
- W1970053105 hasConceptScore W1970053105C140704245 @default.
- W1970053105 hasConceptScore W1970053105C142462285 @default.
- W1970053105 hasConceptScore W1970053105C159047783 @default.
- W1970053105 hasConceptScore W1970053105C203014093 @default.
- W1970053105 hasConceptScore W1970053105C2522874641 @default.
- W1970053105 hasConceptScore W1970053105C2776185481 @default.
- W1970053105 hasConceptScore W1970053105C2779690655 @default.
- W1970053105 hasConceptScore W1970053105C2780727368 @default.
- W1970053105 hasConceptScore W1970053105C2781143361 @default.
- W1970053105 hasConceptScore W1970053105C2993143319 @default.
- W1970053105 hasConceptScore W1970053105C54355233 @default.
- W1970053105 hasConceptScore W1970053105C71924100 @default.
- W1970053105 hasConceptScore W1970053105C86803240 @default.
- W1970053105 hasConceptScore W1970053105C8891405 @default.
- W1970053105 hasIssue "4" @default.
- W1970053105 hasLocation W19700531051 @default.
- W1970053105 hasLocation W19700531052 @default.
- W1970053105 hasOpenAccess W1970053105 @default.
- W1970053105 hasPrimaryLocation W19700531051 @default.
- W1970053105 hasRelatedWork W119293779 @default.
- W1970053105 hasRelatedWork W184675807 @default.
- W1970053105 hasRelatedWork W1970053105 @default.
- W1970053105 hasRelatedWork W2061109312 @default.
- W1970053105 hasRelatedWork W2072794122 @default.
- W1970053105 hasRelatedWork W2129136949 @default.
- W1970053105 hasRelatedWork W2139552123 @default.
- W1970053105 hasRelatedWork W2153977602 @default.
- W1970053105 hasRelatedWork W2156065260 @default.
- W1970053105 hasRelatedWork W2160351640 @default.
- W1970053105 hasVolume "72" @default.
- W1970053105 isParatext "false" @default.
- W1970053105 isRetracted "false" @default.
- W1970053105 magId "1970053105" @default.
- W1970053105 workType "article" @default.