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• W1970053834 endingPage "1899" @default.
• W1970053834 startingPage "1881" @default.
• W1970053834 abstract "A novel and simple approach for rational design of oligosaccharide mimics has been developed. Mammalian highmannose triantennary structure Man9GlcNAc2 has been subjected to molecular modelling using the NMR data available on structural fragments of the oligosaccharide. The analysis indicated four different low energy conformations, and the spatial arrangement of terminal disaccharides of the oligosaccharide antennae were simulated with glycopeptides carrying disaccharides by applying weak constraints between the saccharide parts in MD-simulations on a large array of tri- to octaglycopeptides. The five glycopeptides exhibiting the best fit with the four minimum energy conformations of the oligosaccharide were synthesized by solid phase glycopeptide assembly using glycosylated fluoren-9-ylmethyloxycarbonyl-amino acid-O-pentafluorophenyl esters as building blocks. The glycan was acyl protected α-d-Man-(1→2)-α-d-Man and Ser, Thr and Hyp were the glycosylated amino acids. The deprotected and purified glycopeptides were subjected to NMR analysis for characterization, and in order to investigate the cis-trans isomerism of the carbimide bonds to Hyp. The glycopeptides were tested for their ability to inhibit binding of mannan-binding protein to mannan from Saccharomyces cerevisiae. They were found to be weak inhibitors showing no indication of multivalent interaction with the mannan-binding protein." @default.
• W1970053834 created "2016-06-24" @default.
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• W1970053834 date "1996-11-01" @default.
• W1970053834 modified "2023-09-27" @default.
• W1970053834 title "Glycopeptide mimics of mammalian Man9GlcNAc2. Ligand binding to mannan-binding proteins (MBPs)" @default.
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• W1970053834 doi "https://doi.org/10.1016/s0968-0896(96)00171-x" @default.
• W1970053834 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/9007273" @default.
• W1970053834 hasPublicationYear "1996" @default.
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