Matches in SemOpenAlex for { <https://semopenalex.org/work/W1970056538> ?p ?o ?g. }
Showing items 1 to 70 of
70
with 100 items per page.
- W1970056538 endingPage "3603" @default.
- W1970056538 startingPage "3595" @default.
- W1970056538 abstract "L-iduronic acid, a conformationally flexible monosaccharide, imparts a remarkable protein adaptability to the glycosaminoglycans heparin, heparan sulfate, and dermatan sulfate. The pentasaccharide representing the antithrombin binding site of heparin contains one such L-iduronic acid residue, the conformation of which has been suspected for a long time to be a critical factor in the interaction with antithrombin. We have recently synthesized pentasaccharides containing an L-iduronic acid residue conformationally forced to exist within a restricted arc (2S0 ⇄ 2,5B ⇄ 5S1) of the overall pseudorotational circle. We could thus demonstrate that the 2S0 conformation is adopted upon binding to the protein. In the present work, we now describe the synthesis of a similar pentasaccharide containing a slightly more flexible L-iduronic acid unit with a three-atom bridge between C-2 and C5 of the hexopyranose ring. This pentasaccharide is a better activator of AT-III with respect to blood coagulation factor Xa inhibition. These results confirm that L-iduronic acid adopts an unusual non-chair conformation close to 2S0 and clearly explains how the unique conformational behavior of L-iduronic acid is the key to heparin’s interaction with AT-III. (© Wiley-VCH Verlag GmbH, 69451 Weinheim, Germany, 2002)" @default.
- W1970056538 created "2016-06-24" @default.
- W1970056538 creator A5013179316 @default.
- W1970056538 creator A5024797602 @default.
- W1970056538 creator A5026199225 @default.
- W1970056538 creator A5030328461 @default.
- W1970056538 creator A5032626442 @default.
- W1970056538 creator A5047047835 @default.
- W1970056538 creator A5048252007 @default.
- W1970056538 creator A5065993065 @default.
- W1970056538 creator A5085837006 @default.
- W1970056538 date "2002-11-01" @default.
- W1970056538 modified "2023-10-16" @default.
- W1970056538 title "Further Evidence for the Critical Role of a Non-Chair Conformation of L-Iduronic Acid in the Activation of Antithrombin" @default.
- W1970056538 doi "https://doi.org/10.1002/1099-0690(200211)2002:21<3595::aid-ejoc3595>3.0.co;2-f" @default.
- W1970056538 hasPublicationYear "2002" @default.
- W1970056538 type Work @default.
- W1970056538 sameAs 1970056538 @default.
- W1970056538 citedByCount "13" @default.
- W1970056538 countsByYear W19700565382014 @default.
- W1970056538 countsByYear W19700565382017 @default.
- W1970056538 crossrefType "journal-article" @default.
- W1970056538 hasAuthorship W1970056538A5013179316 @default.
- W1970056538 hasAuthorship W1970056538A5024797602 @default.
- W1970056538 hasAuthorship W1970056538A5026199225 @default.
- W1970056538 hasAuthorship W1970056538A5030328461 @default.
- W1970056538 hasAuthorship W1970056538A5032626442 @default.
- W1970056538 hasAuthorship W1970056538A5047047835 @default.
- W1970056538 hasAuthorship W1970056538A5048252007 @default.
- W1970056538 hasAuthorship W1970056538A5065993065 @default.
- W1970056538 hasAuthorship W1970056538A5085837006 @default.
- W1970056538 hasConcept C185592680 @default.
- W1970056538 hasConcept C2777557582 @default.
- W1970056538 hasConcept C2778041096 @default.
- W1970056538 hasConcept C2778066728 @default.
- W1970056538 hasConcept C2779026020 @default.
- W1970056538 hasConcept C2779650520 @default.
- W1970056538 hasConcept C2781338088 @default.
- W1970056538 hasConcept C55493867 @default.
- W1970056538 hasConcept C71240020 @default.
- W1970056538 hasConceptScore W1970056538C185592680 @default.
- W1970056538 hasConceptScore W1970056538C2777557582 @default.
- W1970056538 hasConceptScore W1970056538C2778041096 @default.
- W1970056538 hasConceptScore W1970056538C2778066728 @default.
- W1970056538 hasConceptScore W1970056538C2779026020 @default.
- W1970056538 hasConceptScore W1970056538C2779650520 @default.
- W1970056538 hasConceptScore W1970056538C2781338088 @default.
- W1970056538 hasConceptScore W1970056538C55493867 @default.
- W1970056538 hasConceptScore W1970056538C71240020 @default.
- W1970056538 hasIssue "21" @default.
- W1970056538 hasLocation W19700565381 @default.
- W1970056538 hasOpenAccess W1970056538 @default.
- W1970056538 hasPrimaryLocation W19700565381 @default.
- W1970056538 hasRelatedWork W139171011 @default.
- W1970056538 hasRelatedWork W1505366254 @default.
- W1970056538 hasRelatedWork W1969482433 @default.
- W1970056538 hasRelatedWork W1975341020 @default.
- W1970056538 hasRelatedWork W2027812955 @default.
- W1970056538 hasRelatedWork W2052690212 @default.
- W1970056538 hasRelatedWork W2075829402 @default.
- W1970056538 hasRelatedWork W2097539919 @default.
- W1970056538 hasRelatedWork W2156311318 @default.
- W1970056538 hasRelatedWork W2801174869 @default.
- W1970056538 hasVolume "2002" @default.
- W1970056538 isParatext "false" @default.
- W1970056538 isRetracted "false" @default.
- W1970056538 magId "1970056538" @default.
- W1970056538 workType "article" @default.