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- W1970060963 abstract "The structural organization of the amyloidogenic β-proteins containing 40 amino acid residues (Aβ40) was studied by the high temperature molecular dynamics simulations in the acidic (pH~3) and basic (pH~8) pH regions. The obtained data suggest that the central Ala21-Gly29 segment of Aβ40, can adopt folded and partially unfolded structures. At the basic pH, this segment forms folded structures, stabilized by electrostatic interactions and hydrogen bonds. At the acidic pH, it forms partially unfolded structures. Two other segments flanking to the central segment exhibit the propensity to adopt unstable inter-converting α-helical, 310-helical and turn-like structures. One of these segments is comprised of the Ala30-Val36 residues at both of the considered pHs. The second segment is comprised of the Glu11-Phe20 at the basic pH and of the Glu11-Val24 residues at the acidic pHs. The revealed pH-dependent structuration of the Aβ40 allowed us to suggest a possible scenario for initial Aβ aggregation. According to this scenario, the occurrence of the partially unfolded states of the Ala21-Gly29 segment plays main role in the Aβ oligomerization process." @default.
- W1970060963 created "2016-06-24" @default.
- W1970060963 creator A5020066689 @default.
- W1970060963 creator A5085651436 @default.
- W1970060963 creator A5089829678 @default.
- W1970060963 date "2009-01-01" @default.
- W1970060963 modified "2023-10-06" @default.
- W1970060963 title "Dynamic properties of pH-dependent structural organization of the amyloidogenic β-protein (1-40)" @default.
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- W1970060963 doi "https://doi.org/10.4161/pri.3.1.8388" @default.
- W1970060963 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2676741" @default.
- W1970060963 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/19372746" @default.
- W1970060963 hasPublicationYear "2009" @default.
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