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• W1970069945 endingPage "e1000284" @default.
• W1970069945 startingPage "e1000284" @default.
• W1970069945 abstract "Small molecules have been shown to be potent and selective probes to understand cell physiology. Here, we show that imidazo[1,2-a]pyridines and imidazo[1,2-a]pyrimidines compose a class of compounds that target essential, conserved cellular processes. Using validated chemogenomic assays in Saccharomyces cerevisiae, we discovered that two closely related compounds, an imidazo[1,2-a]pyridine and -pyrimidine that differ by a single atom, have distinctly different mechanisms of action in vivo. 2-phenyl-3-nitroso-imidazo[1,2-a]pyridine was toxic to yeast strains with defects in electron transport and mitochondrial functions and caused mitochondrial fragmentation, suggesting that compound 13 acts by disrupting mitochondria. By contrast, 2-phenyl-3-nitroso-imidazo[1,2-a]pyrimidine acted as a DNA poison, causing damage to the nuclear DNA and inducing mutagenesis. We compared compound 15 to known chemotherapeutics and found resistance required intact DNA repair pathways. Thus, subtle changes in the structure of imidazo-pyridines and -pyrimidines dramatically alter both the intracellular targeting of these compounds and their effects in vivo. Of particular interest, these different modes of action were evident in experiments on human cells, suggesting that chemical–genetic profiles obtained in yeast are recapitulated in cultured cells, indicating that our observations in yeast can: (1) be leveraged to determine mechanism of action in mammalian cells and (2) suggest novel structure–activity relationships." @default.
• W1970069945 created "2016-06-24" @default.
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• W1970069945 date "2008-11-28" @default.
• W1970069945 modified "2023-10-17" @default.
• W1970069945 title "Chemical–Genetic Profiling of Imidazo[1,2-a]pyridines and -Pyrimidines Reveals Target Pathways Conserved between Yeast and Human Cells" @default.
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• W1970069945 doi "https://doi.org/10.1371/journal.pgen.1000284" @default.
• W1970069945 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2583946" @default.
• W1970069945 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/19043571" @default.
• W1970069945 hasPublicationYear "2008" @default.
• W1970069945 type Work @default.
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