FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1970070519> ?p ?o ?g. }

• W1970070519 endingPage "e8" @default.
• W1970070519 startingPage "e8" @default.
• W1970070519 abstract "Interactions between genes and proteins are crucial for efficient processing of internal or external signals, but this connectivity also amplifies stochastic fluctuations by propagating noise between components. Linear (unbranched) cascades were shown to exhibit an interplay between the sensitivity to changes in input signals and the ability to buffer noise. We searched for biological circuits that can maintain signaling sensitivity while minimizing noise propagation, focusing on cases where the noise is characterized by rapid fluctuations. Negative feedback can buffer this type of noise, but this buffering comes at the expense of an even greater reduction in signaling sensitivity. By systematically analyzing three-component circuits, we identify positive feedback as a central motif allowing for the buffering of propagated noise while maintaining sensitivity to long-term changes in input signals. We show analytically that noise reduction in the presence of positive feedback results from improved averaging of rapid fluctuations over time, and discuss in detail a particular implementation in the control of nutrient homeostasis in yeast. As the design of biological networks optimizes for multiple constraints, positive feedback can be used to improve sensitivity without a compromise in the ability to buffer propagated noise." @default.
• W1970070519 created "2016-06-24" @default.
• W1970070519 creator A5001182042 @default.
• W1970070519 creator A5025741294 @default.
• W1970070519 date "2008-01-04" @default.
• W1970070519 modified "2023-10-12" @default.
• W1970070519 title "Noise Propagation and Signaling Sensitivity in Biological Networks: A Role for Positive Feedback" @default.
• W1970070519 cites W1590222219 @default.
• W1970070519 cites W1966311386 @default.
• W1970070519 cites W1966638085 @default.
• W1970070519 cites W1987815409 @default.
• W1970070519 cites W1988791304 @default.
• W1970070519 cites W2032901621 @default.
• W1970070519 cites W2033736814 @default.
• W1970070519 cites W2037400649 @default.
• W1970070519 cites W2042321087 @default.
• W1970070519 cites W2044692345 @default.
• W1970070519 cites W2045776897 @default.
• W1970070519 cites W2059053384 @default.
• W1970070519 cites W2065219357 @default.
• W1970070519 cites W2078734278 @default.
• W1970070519 cites W2097842145 @default.
• W1970070519 cites W2107342968 @default.
• W1970070519 cites W2109110326 @default.
• W1970070519 cites W2109117831 @default.
• W1970070519 cites W2110071847 @default.
• W1970070519 cites W2113106276 @default.
• W1970070519 cites W2115708039 @default.
• W1970070519 cites W2122121413 @default.
• W1970070519 cites W2124621918 @default.
• W1970070519 cites W2137088684 @default.
• W1970070519 cites W2140347764 @default.
• W1970070519 cites W2147745135 @default.
• W1970070519 cites W2148043530 @default.
• W1970070519 cites W2158469604 @default.
• W1970070519 cites W571141297 @default.
• W1970070519 doi "https://doi.org/10.1371/journal.pcbi.0040008" @default.
• W1970070519 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2174979" @default.
• W1970070519 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/18179281" @default.
• W1970070519 hasPublicationYear "2008" @default.
• W1970070519 type Work @default.
• W1970070519 sameAs 1970070519 @default.
• W1970070519 citedByCount "192" @default.
• W1970070519 countsByYear W19700705192012 @default.
• W1970070519 countsByYear W19700705192013 @default.
• W1970070519 countsByYear W19700705192014 @default.
• W1970070519 countsByYear W19700705192015 @default.
• W1970070519 countsByYear W19700705192016 @default.
• W1970070519 countsByYear W19700705192017 @default.
• W1970070519 countsByYear W19700705192018 @default.
• W1970070519 countsByYear W19700705192019 @default.
• W1970070519 countsByYear W19700705192020 @default.
• W1970070519 countsByYear W19700705192021 @default.
• W1970070519 countsByYear W19700705192022 @default.
• W1970070519 countsByYear W19700705192023 @default.
• W1970070519 crossrefType "journal-article" @default.
• W1970070519 hasAuthorship W1970070519A5001182042 @default.
• W1970070519 hasAuthorship W1970070519A5025741294 @default.
• W1970070519 hasBestOaLocation W19700705191 @default.
• W1970070519 hasConcept C114614502 @default.
• W1970070519 hasConcept C115961682 @default.
• W1970070519 hasConcept C119599485 @default.
• W1970070519 hasConcept C121332964 @default.
• W1970070519 hasConcept C127413603 @default.
• W1970070519 hasConcept C138885662 @default.
• W1970070519 hasConcept C152662350 @default.
• W1970070519 hasConcept C154945302 @default.
• W1970070519 hasConcept C16210155 @default.
• W1970070519 hasConcept C163294075 @default.
• W1970070519 hasConcept C165801399 @default.
• W1970070519 hasConcept C184720557 @default.
• W1970070519 hasConcept C186060115 @default.
• W1970070519 hasConcept C21200559 @default.
• W1970070519 hasConcept C24326235 @default.
• W1970070519 hasConcept C2775924081 @default.
• W1970070519 hasConcept C33923547 @default.
• W1970070519 hasConcept C41008148 @default.
• W1970070519 hasConcept C41895202 @default.
• W1970070519 hasConcept C47446073 @default.
• W1970070519 hasConcept C48207687 @default.
• W1970070519 hasConcept C60644358 @default.
• W1970070519 hasConcept C62520636 @default.
• W1970070519 hasConcept C86803240 @default.
• W1970070519 hasConcept C93586867 @default.
• W1970070519 hasConcept C99498987 @default.
• W1970070519 hasConceptScore W1970070519C114614502 @default.
• W1970070519 hasConceptScore W1970070519C115961682 @default.
• W1970070519 hasConceptScore W1970070519C119599485 @default.
• W1970070519 hasConceptScore W1970070519C121332964 @default.
• W1970070519 hasConceptScore W1970070519C127413603 @default.
• W1970070519 hasConceptScore W1970070519C138885662 @default.
• W1970070519 hasConceptScore W1970070519C152662350 @default.
• W1970070519 hasConceptScore W1970070519C154945302 @default.
• W1970070519 hasConceptScore W1970070519C16210155 @default.
• W1970070519 hasConceptScore W1970070519C163294075 @default.
• W1970070519 hasConceptScore W1970070519C165801399 @default.
• W1970070519 hasConceptScore W1970070519C184720557 @default.
• W1970070519 hasConceptScore W1970070519C186060115 @default.

• next