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- W1970075441 abstract "Pineal melatonin synthesis (serotonin --> N-acetylserotonin --> melatonin) is severely compromised in most inbred strains of mice, in many cases because serotonin is not acetylated by serotonin N-acetyltransferase (arylalkylamine N-acetyltransferase, AANAT). We have found that in the C57BL/6J strain, AANAT mRNA encodes a severely truncated AANAT protein, because a pseudo-exon containing a stop codon is spliced in. This is the first identification of a natural mutation which knocks down melatonin synthesis. The decrease in melatonin signaling may have been a selective factor in the development of laboratory strains of mice because melatonin can inhibit reproduction and modify circadian rhythmicity." @default.
- W1970075441 created "2016-06-24" @default.
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- W1970075441 date "1998-12-01" @default.
- W1970075441 modified "2023-10-10" @default.
- W1970075441 title "Natural melatonin `knockdown' in C57BL/6J mice: rare mechanism truncates serotonin N-acetyltransferase" @default.
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- W1970075441 doi "https://doi.org/10.1016/s0169-328x(98)00273-3" @default.
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