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- W1970076063 abstract "Protein kinase C (PKC) belongs to a family of ten serine/threonine protein kinases encoded by nine genes. This family of proteins plays critical roles in signal transduction which results in cell proliferation, survival, differentiation and apoptosis. Due to differential subcellular localization and tissue distribution, each member displays distinct signaling characteristics. In this review, we have summarized the roles of PKC family members in chronic lymphocytic leukemia (CLL). CLL is a heterogeneous hematological disorder with survival ranging from months to decades. PKC isoforms are differentially expressed in CLL and play critical roles in CLL pathogenesis. Thus, isoform-specific PKC inhibitors may be an attractive option for CLL treatment." @default.
- W1970076063 created "2016-06-24" @default.
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- W1970076063 date "2013-10-31" @default.
- W1970076063 modified "2023-09-26" @default.
- W1970076063 title "Protein kinase C (PKC) as a drug target in chronic lymphocytic leukemia" @default.
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- W1970076063 doi "https://doi.org/10.1007/s12032-013-0757-7" @default.
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