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• W1970080384 abstract "ObjectiveTo examine the effects of unopposed estrogen (E) and tibolone therapy on coagulation and natural anticoagulant systems in surgical menopause.DesignA randomized, double-blind, placebo-controlled study.SettingUniversity hospital clinic in Turkey.Patient(s)Ninety healthy surgically postmenopausal women.Intervention(s)Ninety surgically postmenopausal women were randomized into three groups: unopposed conjugated ET (0.625 mg/d, group 1), tibolone (2.5 mg/d, group 2), and identical tablets of placebo (group 3).Main Outcome Measure(s)Effects on parameters in the clotting cascade at baseline and after 24 weeks of treatment.Result(s)After 6 months, fibrinogen, lipoprotein (a), and factor VIIa were decreased, and activated partial thromboplastin time was increased significantly in the ET group compared with in the placebo group. However, tibolone significantly decreased only the serum levels of factor VIIa and factor IX and prolonged the activated partial thromboplastin time, compared with placebo group. In addition, conjugated ET caused a significantly greater decrease in serum fibrinogen level than did tibolone.Conclusion(s)Neither E nor tibolone therapy led to activation of coagulation in the surgically menopausal women. Both preparations changed the overall hemostatic balance to a more fibrinolytic state. To examine the effects of unopposed estrogen (E) and tibolone therapy on coagulation and natural anticoagulant systems in surgical menopause. A randomized, double-blind, placebo-controlled study. University hospital clinic in Turkey. Ninety healthy surgically postmenopausal women. Ninety surgically postmenopausal women were randomized into three groups: unopposed conjugated ET (0.625 mg/d, group 1), tibolone (2.5 mg/d, group 2), and identical tablets of placebo (group 3). Effects on parameters in the clotting cascade at baseline and after 24 weeks of treatment. After 6 months, fibrinogen, lipoprotein (a), and factor VIIa were decreased, and activated partial thromboplastin time was increased significantly in the ET group compared with in the placebo group. However, tibolone significantly decreased only the serum levels of factor VIIa and factor IX and prolonged the activated partial thromboplastin time, compared with placebo group. In addition, conjugated ET caused a significantly greater decrease in serum fibrinogen level than did tibolone. Neither E nor tibolone therapy led to activation of coagulation in the surgically menopausal women. Both preparations changed the overall hemostatic balance to a more fibrinolytic state." @default.
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• W1970080384 date "2007-04-01" @default.
• W1970080384 modified "2023-10-03" @default.
• W1970080384 title "Comparison of the effects of tibolone and estrogen therapy on hemostasis in surgical menopause: a randomized, double-blind, placebo-controlled study" @default.
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• W1970080384 doi "https://doi.org/10.1016/j.fertnstert.2006.08.090" @default.
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