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• W1970085517 abstract "Aim: To assess survival in patients with HIV and viral hepatitis co-infection. Methods: A prospective university clinic cohort of 472 patients with HIV infection who were followed for 8343 patient-months. The outcome measures were the survival from HIV or liver disease assessed by the Kaplan–Meier method. Multivariable analysis using a Cox regression model identified variables associated with mortality. Results: Patients were divided into four subgroups: HIV/hepatitis B virus (HBV) (n = 72), HIV/hepatitis C virus (HCV) (n = 256), multiple hepatitides (n = 18) and HIV alone (n = 126). One hundred and thirty-four patients (28.4%) died during follow-up. Liver mortality was noted in 55 patients, representing 12% of the cohort and 41% of the total mortality. Survival curves were similar in patients with HIV alone and those with any viral hepatitis co-infection. Liver deaths were more common in patients with multiple hepatitides (28%) HIV/HBV (15%), HIV/HCV co-infection (13%) versus HIV alone (6%). Liver mortality was comparable in HIV/HBV as in HIV/HCV co-infected patients and was not associated with gender, ethnicity, age, or mode of infection. HIV deaths were similar in patients co-infected with viral hepatitis compared with those with HIV alone. In patients with viral hepatitis co-infection, initial CD4 cell count > 200 × 106 cells/l and use of highly active antiretroviral therapy (HAART) were associated with significantly reduced liver mortality. Conclusions: Patients with HIV and viral hepatitis had greater liver mortality than patients with HIV alone, but had comparable HIV mortality. Co-infection with hepatitis B is associated with hepatic outcomes similar to hepatitis C. Control of immunosuppression with HAART and CD4 counts > 200 × 106 cells/l are associated with better hepatic outcomes and should be the first priority in patients with HIV and viral hepatitis." @default.
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• W1970085517 date "2004-10-01" @default.
• W1970085517 modified "2023-10-13" @default.
• W1970085517 title "Survival in patients with HIV infection and viral hepatitis B or C" @default.
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• W1970085517 doi "https://doi.org/10.1097/00002030-200410210-00008" @default.
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