FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1970086292> ?p ?o ?g. }

• W1970086292 endingPage "883" @default.
• W1970086292 startingPage "877" @default.
• W1970086292 abstract "Creatine kinase has been utilized as a diagnostic marker for Duchenne muscular dystrophy (DMD), but it correlates less well with the DMD pathological progression. In this study, we hypothesized that muscle-specific microRNAs (miR-1, -133, and -206) in serum may be useful for monitoring the DMD pathological progression, and explored the possibility of these miRNAs as potential non-invasive biomarkers for the disease. By using real-time quantitative reverse transcription-polymerase chain reaction in a randomized and controlled trial, we detected that miR-1, -133, and -206 were significantly over-expressed in the serum of 39 children with DMD (up to 3.20 ± 1.20, 2(-ΔΔCt) ): almost 2- to 4-fold enriched in comparison to samples from the healthy controls (less than 1.15 ± 0.34, 2(-ΔΔCt) ). To determine whether these miRNAs were related to the clinical features of children with DMD, we analyzed the associations compared to creatine kinase. There were very good inverse correlations between the levels of these miRNAs, especially miR-206, and functional performances: high levels corresponded to low muscle strength, muscle function, and quality of life. Moreover, by receiver operating characteristic curves analyses, we revealed that these miRNAs, especially miR-206, were able to discriminate DMD from controls. Thus, miR-206 and other muscle-specific miRNAs in serum are useful for monitoring the DMD pathological progression, and hence as potential non-invasive biomarkers for the disease. There has been a long-standing need for reliable, non-invasive biomarkers for Duchenne muscular dystrophy (DMD). We found that the levels of muscle-specific microRNAs, especially miR-206, in the serum of DMD were 2- to 4-fold higher than in the controls. High levels corresponded to low muscle strength, muscle function, and quality of life (QoL). These miRNAs were able to discriminate DMD from controls by receiver operating characteristic (ROC) curves analyses. Thus, miR-206 and other muscle-specific miRNAs are useful as non-invasive biomarkers for DMD." @default.
• W1970086292 created "2016-06-24" @default.
• W1970086292 creator A5018882786 @default.
• W1970086292 creator A5023408072 @default.
• W1970086292 creator A5029316081 @default.
• W1970086292 creator A5055441139 @default.
• W1970086292 creator A5079885983 @default.
• W1970086292 creator A5080133917 @default.
• W1970086292 date "2014-02-12" @default.
• W1970086292 modified "2023-09-26" @default.
• W1970086292 title "Serum miR-206 and other muscle-specific microRNAs as non-invasive biomarkers for Duchenne muscular dystrophy" @default.
• W1970086292 cites W1966978010 @default.
• W1970086292 cites W1970902340 @default.
• W1970086292 cites W1978523507 @default.
• W1970086292 cites W1986903527 @default.
• W1970086292 cites W1992958292 @default.
• W1970086292 cites W1999113624 @default.
• W1970086292 cites W2016811958 @default.
• W1970086292 cites W2021570223 @default.
• W1970086292 cites W2023004172 @default.
• W1970086292 cites W2038622868 @default.
• W1970086292 cites W2041832370 @default.
• W1970086292 cites W2045209184 @default.
• W1970086292 cites W2046966094 @default.
• W1970086292 cites W2054795920 @default.
• W1970086292 cites W2059088759 @default.
• W1970086292 cites W2068138485 @default.
• W1970086292 cites W2073548665 @default.
• W1970086292 cites W2080732387 @default.
• W1970086292 cites W2083364993 @default.
• W1970086292 cites W2097233439 @default.
• W1970086292 cites W2107277218 @default.
• W1970086292 cites W2114395071 @default.
• W1970086292 cites W2115093090 @default.
• W1970086292 cites W2124358392 @default.
• W1970086292 cites W2125093810 @default.
• W1970086292 cites W2141619720 @default.
• W1970086292 cites W2143053936 @default.
• W1970086292 cites W2149146453 @default.
• W1970086292 cites W2150561990 @default.
• W1970086292 cites W2157741650 @default.
• W1970086292 cites W2158987836 @default.
• W1970086292 cites W2162126890 @default.
• W1970086292 cites W2164481873 @default.
• W1970086292 cites W2341598418 @default.
• W1970086292 cites W4249799605 @default.
• W1970086292 cites W49471222 @default.
• W1970086292 doi "https://doi.org/10.1111/jnc.12662" @default.
• W1970086292 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/24460924" @default.
• W1970086292 hasPublicationYear "2014" @default.
• W1970086292 type Work @default.
• W1970086292 sameAs 1970086292 @default.
• W1970086292 citedByCount "68" @default.
• W1970086292 countsByYear W19700862922014 @default.
• W1970086292 countsByYear W19700862922015 @default.
• W1970086292 countsByYear W19700862922016 @default.
• W1970086292 countsByYear W19700862922017 @default.
• W1970086292 countsByYear W19700862922018 @default.
• W1970086292 countsByYear W19700862922019 @default.
• W1970086292 countsByYear W19700862922020 @default.
• W1970086292 countsByYear W19700862922021 @default.
• W1970086292 countsByYear W19700862922022 @default.
• W1970086292 countsByYear W19700862922023 @default.
• W1970086292 crossrefType "journal-article" @default.
• W1970086292 hasAuthorship W1970086292A5018882786 @default.
• W1970086292 hasAuthorship W1970086292A5023408072 @default.
• W1970086292 hasAuthorship W1970086292A5029316081 @default.
• W1970086292 hasAuthorship W1970086292A5055441139 @default.
• W1970086292 hasAuthorship W1970086292A5079885983 @default.
• W1970086292 hasAuthorship W1970086292A5080133917 @default.
• W1970086292 hasBestOaLocation W19700862921 @default.
• W1970086292 hasConcept C104317684 @default.
• W1970086292 hasConcept C126322002 @default.
• W1970086292 hasConcept C145059251 @default.
• W1970086292 hasConcept C207886595 @default.
• W1970086292 hasConcept C2778943923 @default.
• W1970086292 hasConcept C2779030066 @default.
• W1970086292 hasConcept C2779134260 @default.
• W1970086292 hasConcept C2781197716 @default.
• W1970086292 hasConcept C36880943 @default.
• W1970086292 hasConcept C54355233 @default.
• W1970086292 hasConcept C60644358 @default.
• W1970086292 hasConcept C71924100 @default.
• W1970086292 hasConcept C86803240 @default.
• W1970086292 hasConceptScore W1970086292C104317684 @default.
• W1970086292 hasConceptScore W1970086292C126322002 @default.
• W1970086292 hasConceptScore W1970086292C145059251 @default.
• W1970086292 hasConceptScore W1970086292C207886595 @default.
• W1970086292 hasConceptScore W1970086292C2778943923 @default.
• W1970086292 hasConceptScore W1970086292C2779030066 @default.
• W1970086292 hasConceptScore W1970086292C2779134260 @default.
• W1970086292 hasConceptScore W1970086292C2781197716 @default.
• W1970086292 hasConceptScore W1970086292C36880943 @default.
• W1970086292 hasConceptScore W1970086292C54355233 @default.
• W1970086292 hasConceptScore W1970086292C60644358 @default.
• W1970086292 hasConceptScore W1970086292C71924100 @default.
• W1970086292 hasConceptScore W1970086292C86803240 @default.
• W1970086292 hasIssue "5" @default.

• next