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- W1970086403 abstract "The humoral immune response constitutes an efficient system to protect the organism against diseases caused by invading pathogens. To guarantee a highly efficient defence, the humoral immune system has to be tightly regulated. Two cell subsets in particular, T cells and follicular dendritic cells (FDCs), contribute to the success of these regulation processes. Whereas the particular role of T cells is the elimination of autoreactive clones, the main role of FDCs is to present unprocessed antigen and check B-cell clones for higher affinity. B-cell clones unsuited for improved humoral immune response will be specifically killed. Involvement of Fas-mediated apoptosis might be an additional tool not only in T-cell-mediated regulation, but also in FDC-B cell interaction in the germinal centre." @default.
- W1970086403 created "2016-06-24" @default.
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- W1970086403 date "1999-10-01" @default.
- W1970086403 modified "2023-10-15" @default.
- W1970086403 title "Follicular dendritic cells and T cells: nurses and executioners in the germinal centre reaction" @default.
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- W1970086403 doi "https://doi.org/10.1002/(sici)1096-9896(199910)189:2<147::aid-path433>3.0.co;2-8" @default.
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