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- W1970103114 abstract "Abstract Cell volume regulation is a basic homeostatic mechanism transcendental for the normal physiology and function of cells. It is mediated principally by the activation of osmolyte transport pathways that result in net changes in solute concentration that counteract cell volume challenges in its constancy. This process has been described to be regulated by a complex assortment of intracellular signal transduction cascades. Recently, several studies have demonstrated that alterations in cell volume induce the release of a wide variety of transmitters including hormones, ATP and neurotransmitters, which have been proposed to act as extracellular signals that regulate the activation of cell volume regulatory mechanisms. In addition, changes in cell volume have also been reported to activate plasma membrane receptors (including tyrosine kinase receptors, G‐protein coupled receptors and integrins) that have been demonstrated to participate in the regulatory process of cell volume. In this review, we summarize recent studies about the role of changes in cell volume in the regulation of transmitter release as well as in the activation of plasma membrane receptors and their further implications in the regulation of the signaling machinery that regulates the activation of osmolyte flux pathways. We propose that the autocrine regulation of Ca 2+ ‐dependent and tyrosine phosphorylation‐dependent signaling pathways by the activation of plasma membrane receptors and swelling‐induced transmitter release is necessary for the activation/regulation of osmolyte efflux pathways and cell volume recovery. Furthermore, we emphasize the importance of studying these extrinsic signals because of their significance in the understanding of the physiology of cell volume regulation and its role in cell biology in vivo, where the constraint of the extracellular space might enhance the autocrine or even paracrine signaling induced by these released transmitters. J. Cell. Physiol. 216: 14–28, 2008. © 2008 Wiley‐Liss, Inc." @default.
- W1970103114 created "2016-06-24" @default.
- W1970103114 creator A5009015359 @default.
- W1970103114 creator A5022987454 @default.
- W1970103114 creator A5039403174 @default.
- W1970103114 date "2008-02-25" @default.
- W1970103114 modified "2023-10-11" @default.
- W1970103114 title "Autocrine signaling involved in cell volume regulation: The role of released transmitters and plasma membrane receptors" @default.
- W1970103114 cites W109290794 @default.
- W1970103114 cites W1480544133 @default.
- W1970103114 cites W1497207210 @default.
- W1970103114 cites W1497464986 @default.
- W1970103114 cites W1499221875 @default.
- W1970103114 cites W1500866277 @default.
- W1970103114 cites W1511917665 @default.
- W1970103114 cites W1546123068 @default.
- W1970103114 cites W1573928766 @default.
- W1970103114 cites W158004158 @default.
- W1970103114 cites W1580762299 @default.
- W1970103114 cites W1593826108 @default.
- W1970103114 cites W1598178857 @default.
- W1970103114 cites W1601563281 @default.
- W1970103114 cites W1602371673 @default.
- W1970103114 cites W1654040390 @default.
- W1970103114 cites W166932304 @default.
- W1970103114 cites W1684364264 @default.
- W1970103114 cites W1775099466 @default.
- W1970103114 cites W1921428702 @default.
- W1970103114 cites W1936866440 @default.
- W1970103114 cites W1963901013 @default.
- W1970103114 cites W1964087083 @default.
- W1970103114 cites W1964149842 @default.
- W1970103114 cites W1964505583 @default.
- W1970103114 cites W1965239434 @default.
- W1970103114 cites W1966183236 @default.
- W1970103114 cites W1967061583 @default.
- W1970103114 cites W1967232798 @default.
- W1970103114 cites W1967621441 @default.
- W1970103114 cites W1967672958 @default.
- W1970103114 cites W1968689277 @default.
- W1970103114 cites W1969509501 @default.
- W1970103114 cites W1970009229 @default.
- W1970103114 cites W1970504089 @default.
- W1970103114 cites W1970684711 @default.
- W1970103114 cites W1970977779 @default.
- W1970103114 cites W1971293756 @default.
- W1970103114 cites W1971597564 @default.
- W1970103114 cites W1972060719 @default.
- W1970103114 cites W1972127397 @default.
- W1970103114 cites W1973293485 @default.
- W1970103114 cites W1973333921 @default.
- W1970103114 cites W1973929320 @default.
- W1970103114 cites W1974032863 @default.
- W1970103114 cites W1974155494 @default.
- W1970103114 cites W1974509476 @default.
- W1970103114 cites W1974654773 @default.
- W1970103114 cites W1975880962 @default.
- W1970103114 cites W1976307713 @default.
- W1970103114 cites W1979109010 @default.
- W1970103114 cites W1980041137 @default.
- W1970103114 cites W1980598881 @default.
- W1970103114 cites W1983449340 @default.
- W1970103114 cites W1984826335 @default.
- W1970103114 cites W1984927454 @default.
- W1970103114 cites W1987751707 @default.
- W1970103114 cites W1988636867 @default.
- W1970103114 cites W1988718438 @default.
- W1970103114 cites W1989438909 @default.
- W1970103114 cites W1989724803 @default.
- W1970103114 cites W1990987463 @default.
- W1970103114 cites W1991341632 @default.
- W1970103114 cites W1991870376 @default.
- W1970103114 cites W1991935222 @default.
- W1970103114 cites W1992193255 @default.
- W1970103114 cites W1994038425 @default.
- W1970103114 cites W1994538204 @default.
- W1970103114 cites W1994757585 @default.
- W1970103114 cites W1995065584 @default.
- W1970103114 cites W1995994950 @default.
- W1970103114 cites W1997480962 @default.
- W1970103114 cites W1997727989 @default.
- W1970103114 cites W1997741064 @default.
- W1970103114 cites W1997965978 @default.
- W1970103114 cites W1998597603 @default.
- W1970103114 cites W1999177230 @default.
- W1970103114 cites W1999238041 @default.
- W1970103114 cites W2000089853 @default.
- W1970103114 cites W2000630926 @default.
- W1970103114 cites W2000702715 @default.
- W1970103114 cites W2001453486 @default.
- W1970103114 cites W2001745716 @default.
- W1970103114 cites W2002279457 @default.
- W1970103114 cites W2003558607 @default.
- W1970103114 cites W2005161329 @default.
- W1970103114 cites W2005313327 @default.
- W1970103114 cites W2007320163 @default.
- W1970103114 cites W2007910821 @default.
- W1970103114 cites W2010390902 @default.