Matches in SemOpenAlex for { <https://semopenalex.org/work/W1970106172> ?p ?o ?g. }
Showing items 1 to 82 of
82
with 100 items per page.
- W1970106172 endingPage "S313" @default.
- W1970106172 startingPage "S313" @default.
- W1970106172 abstract "The cryoprotectant, Dimethyl sulfoxide (DMSO) is known to have toxic side effects in stem cell transplantation. The overall incidence of DMSO toxicity was approximately one in 70 transplants. The mean incidence of DMSO toxicity per center was 2.1%, when 34,000 transplants had been carried out by 95 centers. DMSO exhibits acute mortality at doses of 30 – 40 mg/kg in animals, and fatal arrhythmias, respiratory arrest with diffuse alveolar hemorrhage, seizures, leukoencephalopathy and hemoglobinuria in humans. In light of this, DMSO dose levels per day should be evaluated and certain cutoffs should be mandated for patients' safety. In order to assess risks of toxicity, our center documented the retained plasma levels of DMSO in two patients that were scheduled to receive in excess of 6 bags of autologous units. Standard practice at our institution is to add 10% DMSO per 100 ml bag for cryoprotectant. Each 100 ml bag has 50 ml cells plus 50 ml freeze solution (50% freeze solution = 20% DMSO + 2% heprin + 78% plasmalyte A). Both patients received 6 bags of stem cells on day 1, followed by plasma determination of DMSO. Repeated levels were obtained prior to and following second day of infusion of autologous units. Under gas chromatography, plasma DMSO2 concentration increased during first 24 hrs, plateaued at 4.4 +/- 1.2 mmol/L and remained there for 48 hrs. DMSH2 concentrations were at steady state by 5 min and remained between 3 – 5 mmol/L for 48 hrs. Renal clearance of DMSO was 14.1 +/- 3.4 ml/min. The DMSO dose used and the plasma clearance rates in two different patients are shown in the graphs below.Figure 2View Large Image Figure ViewerDownload Hi-res image Download (PPT) Based on DMSO clearance rates one would expect clearance of DMSO to be higher than what was clinically found. We believe, this highlights the importance of other factors that can decrease DMSO clearance rates during stem cell transplant. For this reason, limit setting of 100 mg of DMSO per day would be a reasonable to avoid increased levels of toxicity. Based on this algorithm, our center has mandated no more than 6 autologous units be infused per day (SOP 117 OU Medical Center)." @default.
- W1970106172 created "2016-06-24" @default.
- W1970106172 creator A5001417224 @default.
- W1970106172 creator A5029557109 @default.
- W1970106172 creator A5081095677 @default.
- W1970106172 date "2013-02-01" @default.
- W1970106172 modified "2023-09-26" @default.
- W1970106172 title "Retrospective Analysis of Intravenous DMSO Toxicity in Transplant Patients" @default.
- W1970106172 doi "https://doi.org/10.1016/j.bbmt.2012.11.466" @default.
- W1970106172 hasPublicationYear "2013" @default.
- W1970106172 type Work @default.
- W1970106172 sameAs 1970106172 @default.
- W1970106172 citedByCount "3" @default.
- W1970106172 countsByYear W19701061722020 @default.
- W1970106172 countsByYear W19701061722021 @default.
- W1970106172 countsByYear W19701061722023 @default.
- W1970106172 crossrefType "journal-article" @default.
- W1970106172 hasAuthorship W1970106172A5001417224 @default.
- W1970106172 hasAuthorship W1970106172A5029557109 @default.
- W1970106172 hasAuthorship W1970106172A5081095677 @default.
- W1970106172 hasBestOaLocation W19701061721 @default.
- W1970106172 hasConcept C116263406 @default.
- W1970106172 hasConcept C120665830 @default.
- W1970106172 hasConcept C121332964 @default.
- W1970106172 hasConcept C126322002 @default.
- W1970106172 hasConcept C141071460 @default.
- W1970106172 hasConcept C178790620 @default.
- W1970106172 hasConcept C179933525 @default.
- W1970106172 hasConcept C185592680 @default.
- W1970106172 hasConcept C196843134 @default.
- W1970106172 hasConcept C2778452553 @default.
- W1970106172 hasConcept C2779365888 @default.
- W1970106172 hasConcept C2911091166 @default.
- W1970106172 hasConcept C29730261 @default.
- W1970106172 hasConcept C42219234 @default.
- W1970106172 hasConcept C61511704 @default.
- W1970106172 hasConcept C68528507 @default.
- W1970106172 hasConcept C71924100 @default.
- W1970106172 hasConcept C86803240 @default.
- W1970106172 hasConcept C90924648 @default.
- W1970106172 hasConcept C95444343 @default.
- W1970106172 hasConceptScore W1970106172C116263406 @default.
- W1970106172 hasConceptScore W1970106172C120665830 @default.
- W1970106172 hasConceptScore W1970106172C121332964 @default.
- W1970106172 hasConceptScore W1970106172C126322002 @default.
- W1970106172 hasConceptScore W1970106172C141071460 @default.
- W1970106172 hasConceptScore W1970106172C178790620 @default.
- W1970106172 hasConceptScore W1970106172C179933525 @default.
- W1970106172 hasConceptScore W1970106172C185592680 @default.
- W1970106172 hasConceptScore W1970106172C196843134 @default.
- W1970106172 hasConceptScore W1970106172C2778452553 @default.
- W1970106172 hasConceptScore W1970106172C2779365888 @default.
- W1970106172 hasConceptScore W1970106172C2911091166 @default.
- W1970106172 hasConceptScore W1970106172C29730261 @default.
- W1970106172 hasConceptScore W1970106172C42219234 @default.
- W1970106172 hasConceptScore W1970106172C61511704 @default.
- W1970106172 hasConceptScore W1970106172C68528507 @default.
- W1970106172 hasConceptScore W1970106172C71924100 @default.
- W1970106172 hasConceptScore W1970106172C86803240 @default.
- W1970106172 hasConceptScore W1970106172C90924648 @default.
- W1970106172 hasConceptScore W1970106172C95444343 @default.
- W1970106172 hasIssue "2" @default.
- W1970106172 hasLocation W19701061721 @default.
- W1970106172 hasOpenAccess W1970106172 @default.
- W1970106172 hasPrimaryLocation W19701061721 @default.
- W1970106172 hasRelatedWork W1964971016 @default.
- W1970106172 hasRelatedWork W2079472334 @default.
- W1970106172 hasRelatedWork W2087459572 @default.
- W1970106172 hasRelatedWork W2091541550 @default.
- W1970106172 hasRelatedWork W2126328464 @default.
- W1970106172 hasRelatedWork W2398828867 @default.
- W1970106172 hasRelatedWork W3018041402 @default.
- W1970106172 hasRelatedWork W3140855078 @default.
- W1970106172 hasRelatedWork W4220787980 @default.
- W1970106172 hasRelatedWork W2737186227 @default.
- W1970106172 hasVolume "19" @default.
- W1970106172 isParatext "false" @default.
- W1970106172 isRetracted "false" @default.
- W1970106172 magId "1970106172" @default.
- W1970106172 workType "article" @default.