Matches in SemOpenAlex for { <https://semopenalex.org/work/W1970110689> ?p ?o ?g. }
- W1970110689 endingPage "553" @default.
- W1970110689 startingPage "539" @default.
- W1970110689 abstract "Atherosclerosis is a continuous pathological process that starts early in life and progresses frequently to unstable plaques. Plaque rupture leads to deleterious consequences such as acute coronary syndrome, stroke and atherothrombosis. The vulnerable lesion has several structural and functional hallmarks that distinguish it from the stable plaque. The unstable plaque has large necrotic core (over 40% plaque volume) composed of cholesterol crystals, cholesterol esters, oxidized lipids, fibrin, erythrocytes and their remnants (haeme, iron, haemoglobin), and dying macrophages. The fibrous cap is thin, depleted of smooth muscle cells and collagen, and is infiltrated with proinflammatory cells. In unstable lesion, formation of neomicrovessels is increased. These neovessels have weak integrity and leak thereby leading to recurrent haemorrhages. Haemorrhages deliver erythrocytes to the necrotic core where they degrade promoting inflammation and oxidative stress. Inflammatory cells mostly presented by monocytes/macrophages, neutrophils and mast cells extravagate from bleeding neovessels and infiltrate adventitia where they support chronic inflammation. Plaque destabilization is an evolutionary process that could start at early atherosclerotic stages and whose progression is influenced by many factors including neovascularization, intraplaque haemorrhages, formation of cholesterol crystals, inflammation, oxidative stress and intraplaque protease activity." @default.
- W1970110689 created "2016-06-24" @default.
- W1970110689 creator A5011643232 @default.
- W1970110689 creator A5043145631 @default.
- W1970110689 creator A5075043020 @default.
- W1970110689 date "2015-01-02" @default.
- W1970110689 modified "2023-10-18" @default.
- W1970110689 title "Contribution of neovascularization and intraplaque haemorrhage to atherosclerotic plaque progression and instability" @default.
- W1970110689 cites W1525484196 @default.
- W1970110689 cites W1533177616 @default.
- W1970110689 cites W1540228280 @default.
- W1970110689 cites W1581404300 @default.
- W1970110689 cites W1602214891 @default.
- W1970110689 cites W1929217452 @default.
- W1970110689 cites W1965760510 @default.
- W1970110689 cites W1967923317 @default.
- W1970110689 cites W1968148355 @default.
- W1970110689 cites W1969154852 @default.
- W1970110689 cites W1971483066 @default.
- W1970110689 cites W1972341792 @default.
- W1970110689 cites W1972483153 @default.
- W1970110689 cites W1973447539 @default.
- W1970110689 cites W1973863710 @default.
- W1970110689 cites W1975058097 @default.
- W1970110689 cites W1978182599 @default.
- W1970110689 cites W1980841695 @default.
- W1970110689 cites W1981192304 @default.
- W1970110689 cites W1981298849 @default.
- W1970110689 cites W1981829503 @default.
- W1970110689 cites W1985981007 @default.
- W1970110689 cites W1986022717 @default.
- W1970110689 cites W1986193462 @default.
- W1970110689 cites W1986540698 @default.
- W1970110689 cites W1987586330 @default.
- W1970110689 cites W1987620109 @default.
- W1970110689 cites W1987941106 @default.
- W1970110689 cites W1988813823 @default.
- W1970110689 cites W1989254741 @default.
- W1970110689 cites W1989511609 @default.
- W1970110689 cites W1992125460 @default.
- W1970110689 cites W1992960059 @default.
- W1970110689 cites W1994840834 @default.
- W1970110689 cites W1994980657 @default.
- W1970110689 cites W1995245040 @default.
- W1970110689 cites W1995941626 @default.
- W1970110689 cites W1998815954 @default.
- W1970110689 cites W2002131026 @default.
- W1970110689 cites W2003219549 @default.
- W1970110689 cites W2003517508 @default.
- W1970110689 cites W2005874745 @default.
- W1970110689 cites W2010984307 @default.
- W1970110689 cites W2014971932 @default.
- W1970110689 cites W2016345457 @default.
- W1970110689 cites W2017574292 @default.
- W1970110689 cites W2020360618 @default.
- W1970110689 cites W2020425852 @default.
- W1970110689 cites W2021596920 @default.
- W1970110689 cites W2027132059 @default.
- W1970110689 cites W2028545985 @default.
- W1970110689 cites W2032049229 @default.
- W1970110689 cites W2033486658 @default.
- W1970110689 cites W2033671240 @default.
- W1970110689 cites W2037062908 @default.
- W1970110689 cites W2037663465 @default.
- W1970110689 cites W2039019788 @default.
- W1970110689 cites W2040746659 @default.
- W1970110689 cites W2043909750 @default.
- W1970110689 cites W2044463761 @default.
- W1970110689 cites W2045892982 @default.
- W1970110689 cites W2046443005 @default.
- W1970110689 cites W2047327988 @default.
- W1970110689 cites W2047525024 @default.
- W1970110689 cites W2049402923 @default.
- W1970110689 cites W2051926595 @default.
- W1970110689 cites W2053261582 @default.
- W1970110689 cites W2053275538 @default.
- W1970110689 cites W2054753294 @default.
- W1970110689 cites W2054815702 @default.
- W1970110689 cites W2055655700 @default.
- W1970110689 cites W2056404114 @default.
- W1970110689 cites W2058524076 @default.
- W1970110689 cites W2058555166 @default.
- W1970110689 cites W2061917180 @default.
- W1970110689 cites W2061989529 @default.
- W1970110689 cites W2064429559 @default.
- W1970110689 cites W2064715716 @default.
- W1970110689 cites W2064745690 @default.
- W1970110689 cites W2065069252 @default.
- W1970110689 cites W2068111870 @default.
- W1970110689 cites W2069961866 @default.
- W1970110689 cites W2072374715 @default.
- W1970110689 cites W2074253462 @default.
- W1970110689 cites W2074268312 @default.
- W1970110689 cites W2074602820 @default.
- W1970110689 cites W2075306919 @default.
- W1970110689 cites W2078231557 @default.
- W1970110689 cites W2080225700 @default.
- W1970110689 cites W2081238117 @default.