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- W1970111700 abstract "Individual cultured rat hippocampal neurons grown on glass coverslips were loaded with lucifer yellow (LY) and segments of their dendrites, containing dendritic spines, were exposed to the glutamate agonist N-methyl-d-aspartate (NMDA). Repeated pulse application of NMDA caused a reduction of spine length by 20%, within 1–2 h of exposure to the drug. No such changes were seen in spines exposed to NMDA in presence of the antagonist 2-aminophosphonovalerate or in spines on sister dendrites which were not exposed to NMDA. It is suggested that dendritic spines shrink following exposure to excessive synaptic stimulation." @default.
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- W1970111700 date "1995-06-01" @default.
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- W1970111700 title "Morphological alterations in dendritic spines of rat hippocampal neurons exposed to N-methyl-d-aspartate" @default.
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- W1970111700 doi "https://doi.org/10.1016/0304-3940(95)11665-j" @default.
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