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- W1970116602 abstract "Regulated expression of the recombinase RAG-1 and RAG-2 proteins is necessary for generating the vast repertoire of antigen receptors essential for adaptive immunity. Here, a retroviral cDNA library screen showed that the stress-regulated protein GADD45a activated transcription of the genes encoding RAG-1 and RAG-2 in transformed pro-B cells by a pathway requiring the transcription factor Foxo1. Foxo1 directly activated transcription of the Rag1-Rag2 locus throughout early B cell development, and a decrease in Foxo1 protein diminished the induction of Rag1 and Rag2 transcription in a model of receptor editing. We also found that transcription of Rag1 and Rag2 was repressed at the pro-B cell and immature B cell stages by the kinase Akt through its 'antagonism' of Foxo1 function. Thus, Foxo1 is a key regulator of Rag1 and Rag2 transcription in primary B cells." @default.
- W1970116602 created "2016-06-24" @default.
- W1970116602 creator A5029562882 @default.
- W1970116602 creator A5089034447 @default.
- W1970116602 date "2008-05-11" @default.
- W1970116602 modified "2023-10-17" @default.
- W1970116602 title "Foxo1 directly regulates the transcription of recombination-activating genes during B cell development" @default.
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- W1970116602 doi "https://doi.org/10.1038/ni.1612" @default.
- W1970116602 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2612116" @default.
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