FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1970128455> ?p ?o ?g. }

• W1970128455 endingPage "118" @default.
• W1970128455 startingPage "111" @default.
• W1970128455 abstract "Some forms of hexavalent chromium [Cr(VI)] are known to cause damage to respiratory-tract tissue and DNA and are thought to be human lung carcinogens. In general, Cr(VI) is mutagenic and carcinogenic at doses that also evoke some cell death, and we previously showed that the predominant mode of death is apoptosis. Because p53 has been shown to initiate apoptosis after genotoxic insults, the objective of these experiments was to determine whether p53 is activated in and necessary for apoptosis of normal diploid human lung fibroblasts (HLF cells) after chromium exposure. By using annexin(V) staining and fluorescent microscopy, we found that Cr(VI) caused up to 14% of HLF cells to undergo apoptosis within 24 h after exposure. In addition, by using western blotting, we found that p53 protein levels increased fourfold to sixfold after exposure to sodium chromate. Because the major function of p53 is as a transcription factor, it must be translocated from the cytoplasm to the nucleus after chromate exposure to be active. Immunofluorescence studies using an antibody against p53 showed that, after chromate exposure, p53 was located in the nucleus of the treated HLF cells. The necessity of p53 for chromium-induced apoptosis was examined in two ways. One approach used dermal fibroblasts from p53 wild-type, heterozygous, and null mice, and the other approach used HLF cells that were transiently transfected with the human papilloma virus E6 gene, which targets p53 for degradation and creates a functional p53-null cell. These studies showed that chromium-induced apoptosis was p53 dependent. Mol. Carcinog. 28:111-118, 2000." @default.
• W1970128455 created "2016-06-24" @default.
• W1970128455 creator A5019204638 @default.
• W1970128455 creator A5021059857 @default.
• W1970128455 creator A5029777181 @default.
• W1970128455 creator A5062031610 @default.
• W1970128455 date "2000-01-01" @default.
• W1970128455 modified "2023-10-17" @default.
• W1970128455 title "Chromium(VI) Induces p53-Dependent Apoptosis in Diploid Human Lung and Mouse Dermal Fibroblasts" @default.
• W1970128455 cites W1529655352 @default.
• W1970128455 cites W1560187259 @default.
• W1970128455 cites W1964374342 @default.
• W1970128455 cites W1966311115 @default.
• W1970128455 cites W1975279002 @default.
• W1970128455 cites W1975505076 @default.
• W1970128455 cites W1979112811 @default.
• W1970128455 cites W1980367371 @default.
• W1970128455 cites W1983386156 @default.
• W1970128455 cites W1988545352 @default.
• W1970128455 cites W2006843759 @default.
• W1970128455 cites W2008374272 @default.
• W1970128455 cites W2014836812 @default.
• W1970128455 cites W2016492849 @default.
• W1970128455 cites W2017027282 @default.
• W1970128455 cites W2019416759 @default.
• W1970128455 cites W2024665712 @default.
• W1970128455 cites W2029735450 @default.
• W1970128455 cites W2029816972 @default.
• W1970128455 cites W2030283142 @default.
• W1970128455 cites W2031889409 @default.
• W1970128455 cites W2038817158 @default.
• W1970128455 cites W2040034004 @default.
• W1970128455 cites W2044160040 @default.
• W1970128455 cites W2046895342 @default.
• W1970128455 cites W2048780743 @default.
• W1970128455 cites W2050025977 @default.
• W1970128455 cites W2059379704 @default.
• W1970128455 cites W2060378535 @default.
• W1970128455 cites W2071694775 @default.
• W1970128455 cites W2072804418 @default.
• W1970128455 cites W2105426204 @default.
• W1970128455 cites W2117924481 @default.
• W1970128455 cites W2136046634 @default.
• W1970128455 cites W2141529421 @default.
• W1970128455 cites W2147242002 @default.
• W1970128455 cites W2149967205 @default.
• W1970128455 cites W2166548845 @default.
• W1970128455 cites W2168084973 @default.
• W1970128455 doi "https://doi.org/10.1002/1098-2744(200006)28:2<111::aid-mc7>3.0.co;2-y" @default.
• W1970128455 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/10900468" @default.
• W1970128455 hasPublicationYear "2000" @default.
• W1970128455 type Work @default.
• W1970128455 sameAs 1970128455 @default.
• W1970128455 citedByCount "74" @default.
• W1970128455 countsByYear W19701284552012 @default.
• W1970128455 countsByYear W19701284552013 @default.
• W1970128455 countsByYear W19701284552014 @default.
• W1970128455 countsByYear W19701284552015 @default.
• W1970128455 countsByYear W19701284552017 @default.
• W1970128455 countsByYear W19701284552019 @default.
• W1970128455 countsByYear W19701284552020 @default.
• W1970128455 countsByYear W19701284552021 @default.
• W1970128455 countsByYear W19701284552022 @default.
• W1970128455 crossrefType "journal-article" @default.
• W1970128455 hasAuthorship W1970128455A5019204638 @default.
• W1970128455 hasAuthorship W1970128455A5021059857 @default.
• W1970128455 hasAuthorship W1970128455A5029777181 @default.
• W1970128455 hasAuthorship W1970128455A5062031610 @default.
• W1970128455 hasConcept C143425029 @default.
• W1970128455 hasConcept C153911025 @default.
• W1970128455 hasConcept C190283241 @default.
• W1970128455 hasConcept C2780358455 @default.
• W1970128455 hasConcept C31573885 @default.
• W1970128455 hasConcept C502942594 @default.
• W1970128455 hasConcept C54009773 @default.
• W1970128455 hasConcept C54355233 @default.
• W1970128455 hasConcept C552990157 @default.
• W1970128455 hasConcept C55493867 @default.
• W1970128455 hasConcept C81885089 @default.
• W1970128455 hasConcept C86803240 @default.
• W1970128455 hasConcept C95444343 @default.
• W1970128455 hasConceptScore W1970128455C143425029 @default.
• W1970128455 hasConceptScore W1970128455C153911025 @default.
• W1970128455 hasConceptScore W1970128455C190283241 @default.
• W1970128455 hasConceptScore W1970128455C2780358455 @default.
• W1970128455 hasConceptScore W1970128455C31573885 @default.
• W1970128455 hasConceptScore W1970128455C502942594 @default.
• W1970128455 hasConceptScore W1970128455C54009773 @default.
• W1970128455 hasConceptScore W1970128455C54355233 @default.
• W1970128455 hasConceptScore W1970128455C552990157 @default.
• W1970128455 hasConceptScore W1970128455C55493867 @default.
• W1970128455 hasConceptScore W1970128455C81885089 @default.
• W1970128455 hasConceptScore W1970128455C86803240 @default.
• W1970128455 hasConceptScore W1970128455C95444343 @default.
• W1970128455 hasIssue "2" @default.
• W1970128455 hasLocation W19701284551 @default.
• W1970128455 hasLocation W19701284552 @default.
• W1970128455 hasOpenAccess W1970128455 @default.

• next