Matches in SemOpenAlex for { <https://semopenalex.org/work/W1970132011> ?p ?o ?g. }
- W1970132011 endingPage "611" @default.
- W1970132011 startingPage "595" @default.
- W1970132011 abstract "Formins associate with other nucleators and nucleation-promoting factors (NPFs) to stimulate collaborative actin assembly, but the mechanisms regulating these interactions have been unclear. Yeast Bud6 has an established role as an NPF for the formin Bni1, but whether it also directly regulates the formin Bnr1 has remained enigmatic. In this paper, we analyzed NPF-impaired alleles of bud6 in a bni1Δ background and found that Bud6 stimulated Bnr1 activity in vivo. Furthermore, Bud6 bound directly to Bnr1, but its NPF effects were masked by a short regulatory sequence, suggesting that additional factors may be required for activation. We isolated a novel in vivo binding partner of Bud6, Yor304c-a/Bil1, which colocalized with Bud6 and functioned in the Bnr1 pathway for actin assembly. Purified Bil1 bound to the regulatory sequence in Bud6 and triggered NPF effects on Bnr1. These observations define a new mode of formin regulation, which has important implications for understanding NPF-nucleator pairs in diverse systems." @default.
- W1970132011 created "2016-06-24" @default.
- W1970132011 creator A5020787190 @default.
- W1970132011 creator A5040375481 @default.
- W1970132011 creator A5062225126 @default.
- W1970132011 creator A5071997273 @default.
- W1970132011 creator A5079276517 @default.
- W1970132011 date "2013-05-13" @default.
- W1970132011 modified "2023-10-15" @default.
- W1970132011 title "Ligand-induced activation of a formin–NPF pair leads to collaborative actin nucleation" @default.
- W1970132011 cites W1538692246 @default.
- W1970132011 cites W1557401044 @default.
- W1970132011 cites W1600241919 @default.
- W1970132011 cites W1968603501 @default.
- W1970132011 cites W1969911260 @default.
- W1970132011 cites W1973444064 @default.
- W1970132011 cites W1977222247 @default.
- W1970132011 cites W1979555746 @default.
- W1970132011 cites W1982323979 @default.
- W1970132011 cites W1984374880 @default.
- W1970132011 cites W1986062719 @default.
- W1970132011 cites W1990850141 @default.
- W1970132011 cites W1992885630 @default.
- W1970132011 cites W1995138628 @default.
- W1970132011 cites W1997228602 @default.
- W1970132011 cites W1999017332 @default.
- W1970132011 cites W2008282204 @default.
- W1970132011 cites W2010959934 @default.
- W1970132011 cites W2011017251 @default.
- W1970132011 cites W2011763778 @default.
- W1970132011 cites W2012948303 @default.
- W1970132011 cites W2018212873 @default.
- W1970132011 cites W2019125570 @default.
- W1970132011 cites W2019559746 @default.
- W1970132011 cites W2023434864 @default.
- W1970132011 cites W2025480988 @default.
- W1970132011 cites W2025823358 @default.
- W1970132011 cites W2035115690 @default.
- W1970132011 cites W2036535918 @default.
- W1970132011 cites W2037565201 @default.
- W1970132011 cites W2038657817 @default.
- W1970132011 cites W2047853156 @default.
- W1970132011 cites W2058180077 @default.
- W1970132011 cites W2058655076 @default.
- W1970132011 cites W2062852486 @default.
- W1970132011 cites W2064071063 @default.
- W1970132011 cites W2064774649 @default.
- W1970132011 cites W2066682953 @default.
- W1970132011 cites W2070119451 @default.
- W1970132011 cites W2071199281 @default.
- W1970132011 cites W2071869797 @default.
- W1970132011 cites W2072090189 @default.
- W1970132011 cites W2081875880 @default.
- W1970132011 cites W2086779162 @default.
- W1970132011 cites W2092496829 @default.
- W1970132011 cites W2098278940 @default.
- W1970132011 cites W2105087111 @default.
- W1970132011 cites W2108167818 @default.
- W1970132011 cites W2109248504 @default.
- W1970132011 cites W2116117181 @default.
- W1970132011 cites W2117827556 @default.
- W1970132011 cites W2120121290 @default.
- W1970132011 cites W2123463281 @default.
- W1970132011 cites W2124163523 @default.
- W1970132011 cites W2127073167 @default.
- W1970132011 cites W2127150952 @default.
- W1970132011 cites W2130963344 @default.
- W1970132011 cites W2131316350 @default.
- W1970132011 cites W2135453326 @default.
- W1970132011 cites W2136684091 @default.
- W1970132011 cites W2139849392 @default.
- W1970132011 cites W2142173778 @default.
- W1970132011 cites W2145225799 @default.
- W1970132011 cites W2152159726 @default.
- W1970132011 cites W2153290005 @default.
- W1970132011 cites W2154465669 @default.
- W1970132011 cites W2157379116 @default.
- W1970132011 cites W2159330369 @default.
- W1970132011 cites W2160943729 @default.
- W1970132011 cites W2169805130 @default.
- W1970132011 doi "https://doi.org/10.1083/jcb.201212059" @default.
- W1970132011 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3653363" @default.
- W1970132011 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/23671312" @default.
- W1970132011 hasPublicationYear "2013" @default.
- W1970132011 type Work @default.
- W1970132011 sameAs 1970132011 @default.
- W1970132011 citedByCount "33" @default.
- W1970132011 countsByYear W19701320112013 @default.
- W1970132011 countsByYear W19701320112014 @default.
- W1970132011 countsByYear W19701320112015 @default.
- W1970132011 countsByYear W19701320112016 @default.
- W1970132011 countsByYear W19701320112017 @default.
- W1970132011 countsByYear W19701320112018 @default.
- W1970132011 countsByYear W19701320112019 @default.
- W1970132011 countsByYear W19701320112020 @default.
- W1970132011 countsByYear W19701320112021 @default.
- W1970132011 countsByYear W19701320112022 @default.
- W1970132011 countsByYear W19701320112023 @default.